[将苄索氯铵制成凝胶剂]

[Formulation of benzethonium chloride into gels].

作者信息

Cižmárik Jozef, Vitková Zuzana, Herdová Petra, Kodadová Alexandra, Vími Daniel

出版信息

Ceska Slov Farm. 2014 Jun;63(3):123-6.

Abstract

This study is focused on the preparation of gels with antimicrobial effects. A quaternary ammonium salt, benzethonium chloride, in a concentration of 0.01-0.5% (w/w) was employed as the drug. The humectant employed was propylene glycol in concentrations of 5% and 10% (w/w). Two types of polymers, chitosan and hydroxyethyl cellulose, in the same concentrations of 2.5% (w/w), were used for gel preparation. Finally the flow properties, rheological parameters and pH values of the gels were evaluated. Based on the obtained results, the samples of the gels prepared on the basis of chitosan and hydroxyethyl cellulose, which have the following optimum composition shown below, were found: 2,5% (w/w) CHIT + 0,5% (w/w) BZCl + 10% (w/w) PG; 2,5% (w/w) HEC + 0,5% (w/w) BZCl + 5% (w/w) PG.

摘要

本研究聚焦于具有抗菌作用的凝胶制剂。使用浓度为0.01 - 0.5%（w/w）的季铵盐苯扎氯铵作为药物。所使用的保湿剂为浓度为5%和10%（w/w）的丙二醇。两种聚合物，壳聚糖和羟乙基纤维素，以相同的2.5%（w/w）浓度用于制备凝胶。最后对凝胶的流动性质、流变学参数和pH值进行了评估。基于所得结果，发现了基于壳聚糖和羟乙基纤维素制备的凝胶样品，其具有以下所示的最佳组成：2.5%（w/w）壳聚糖 + 0.5%（w/w）苯扎氯铵 + 10%（w/w）丙二醇；2.5%（w/w）羟乙基纤维素 + 0.5%（w/w）苯扎氯铵 + 5%（w/w）丙二醇。