Department of Dermatology, Najafabad Branch, Islamic Azad University, Najafabad, Iran.
Dermatol Surg. 2014 Jan;40(1):33-7. doi: 10.1111/dsu.12296. Epub 2013 Nov 14.
Zinc plays a role in skin health, and preliminary data have shown its beneficial effects for melasma. We compared the effect of topical zinc with that of hydroquinone as the standard treatment on severity of melasma.
Ninety-three women with melasma were randomized to receive zinc sulfate 10% or hydroquinone 4% solutions once daily for 2 months. They were followed for an additional 3 months while using sunscreen. The severity of melasma was assessed at baseline and at 2 and 5 months using the Melasma Area and Severity Index (MASI).
Eighty-two patients completed the study. The MASI score fell significantly in both groups, but a greater decrease was seen in those who received hydroquinone (43.5 ± 15.5% vs 18.6 ± 20.8%, p < .001). Postinflammatory pigmentation occurred in 5.2% of the zinc group and irritation in 30.9% of the hydroquinone group.
Topical zinc therapy is not highly effective in reducing the severity of melasma, but further trials are needed to determine whether adding zinc to current topical treatments could improve treatment response.
锌在皮肤健康中发挥作用，初步数据显示其对黄褐斑有益。我们比较了局部使用锌与标准治疗药物氢醌对黄褐斑严重程度的影响。
93 名黄褐斑女性患者随机分为两组，分别接受 10%硫酸锌或 4%氢醌溶液，每天一次，持续 2 个月。在使用防晒霜的情况下，再随访 3 个月。在基线、2 个月和 5 个月时使用黄褐斑面积和严重程度指数（MASI）评估黄褐斑的严重程度。
82 名患者完成了研究。两组的 MASI 评分均显著下降，但接受氢醌治疗的患者下降更明显（43.5±15.5%比 18.6±20.8%，p<0.001）。锌组有 5.2%的患者出现炎症后色素沉着，而氢醌组有 30.9%的患者出现刺激。
局部使用锌治疗对减轻黄褐斑严重程度的效果并不显著，但需要进一步的试验来确定在当前的局部治疗中添加锌是否可以改善治疗反应。
