Siribumrungwong Boonying, Srikuea Kanoklada, Thakkinstian Ammarin
Department of Surgery, Thammasat University Hospital, Thammasat University Rangsit Campus, Pathumthani, Thailand; Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Department of Surgery, Thammasat University Hospital, Thammasat University Rangsit Campus, Pathumthani, Thailand.
Asian J Surg. 2014 Jul;37(3):120-4. doi: 10.1016/j.asjsur.2013.09.007. Epub 2013 Nov 12.
Delayed primary (DPC) and primary (PC) wound closures have been applied in ruptured appendicitis, but results were controversial. This study aims at comparing the rate of superficial surgical site infection (SSI) in ruptured appendicitis between DPC and PC.
A retrospective cohort of ruptured appendicitis was conducted between October 2006 and November 2009. Demographic, operative findings and postoperative infection data were retrieved. The superficial SSI rates between groups were compared using an exact test. An odds ratio of SSI was then estimated.
One-hundred and twenty eight patients with ruptured appendicitis were eligible and their data were retrieved; 115 (90%) patients had received DPC and 13 (10%) patients had received PC. The SSI rate was much lower in PC patients than in DPC patients, i.e., 7.7% [95% confidence interval (CI): 0.02, 36.0] versus 27.8% (95% CI: 19.9, 37.0), respectively. There was an approximately 72% lower risk of SSI in the PC group than in the DPC group, but this did not reach statistical significance (p = 0.18).
Our study suggested that PC does not increase risk of SSI in low SSI risk patients with ruptured appendicitis. DPC should not be routinely done.
延迟一期(DPC)和一期(PC)伤口缝合已应用于阑尾破裂,但结果存在争议。本研究旨在比较DPC和PC治疗阑尾破裂时的浅表手术部位感染(SSI)发生率。
对2006年10月至2009年11月期间阑尾破裂患者进行回顾性队列研究。收集人口统计学、手术结果和术后感染数据。采用精确检验比较两组间的浅表SSI发生率,然后估计SSI的比值比。
128例阑尾破裂患者符合条件并收集了其数据;115例(90%)患者接受了DPC,13例(10%)患者接受了PC。PC组患者的SSI发生率远低于DPC组患者,分别为7.7% [95%置信区间(CI):0.02, 36.0]和27.8%(95% CI:19.9, 37.0)。PC组的SSI风险比DPC组低约72%,但未达到统计学显著性(p = 0.18)。
我们的研究表明,对于阑尾破裂且SSI风险较低的患者,PC不会增加SSI风险。不应常规进行DPC。