The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Neuron. 2013 Dec 4;80(5):1277-89. doi: 10.1016/j.neuron.2013.08.037. Epub 2013 Nov 14.
Interactions between cortex and hippocampus are believed to play a role in the acquisition and maintenance of memories. Distinct types of coordinated oscillatory activity, namely at theta frequency, are hypothesized to regulate information processing in these structures. We investigated how information processing in cingulate cortex and hippocampus relates to cingulate-hippocampus coordination in a behavioral task in which rats choose from four possible trajectories according to a sequence. We found that the accuracy with which cingulate and hippocampal populations encode individual trajectories changes with the pattern of cingulate-hippocampal theta coherence over the course of a trial. Initial theta coherence at ~8 Hz during trial onsets lowers by ~1 Hz as animals enter decision stages. At these stages, hippocampus precedes cingulate in processing increased amounts of task-relevant information. We hypothesize that lower theta frequency coordinates the integration of hippocampal contextual information by cingulate neuronal populations, to inform choices in a task-phase-dependent manner.
皮质和海马体之间的相互作用被认为在记忆的获取和维持中发挥作用。假设在这些结构中，以 theta 频率为特征的不同类型的协调振荡活动调节信息处理。我们研究了在一项行为任务中，当大鼠根据序列从四个可能的轨迹中选择时，扣带回皮层和海马体的信息处理与扣带回-海马体协调之间的关系。我们发现，扣带回和海马体群体对个体轨迹的编码准确性随着试验过程中扣带回-海马体 theta 相干性的模式而变化。在试验开始时，约 8 Hz 的初始 theta 相干性在动物进入决策阶段时降低约 1 Hz。在这些阶段，海马体在处理与任务相关的信息量增加方面先于扣带回。我们假设，较低的 theta 频率通过扣带回神经元群体协调海马体上下文信息的整合，以任务相位依赖的方式为选择提供信息。
