Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA.
J Neurosci. 2012 Jan 11;32(2):423-35. doi: 10.1523/JNEUROSCI.4122-11.2012.
Neuronal oscillations allow for temporal segmentation of neuronal spikes. Interdependent oscillators can integrate multiple layers of information. We examined phase-phase coupling of theta and gamma oscillators in the CA1 region of rat hippocampus during maze exploration and rapid eye movement sleep. Hippocampal theta waves were asymmetric, and estimation of the spatial position of the animal was improved by identifying the waveform-based phase of spiking, compared to traditional methods used for phase estimation. Using the waveform-based theta phase, three distinct gamma bands were identified: slow gamma(S) (gamma(S); 30-50 Hz), midfrequency gamma(M) (gamma(M); 50-90 Hz), and fast gamma(F) (gamma(F); 90-150 Hz or epsilon band). The amplitude of each sub-band was modulated by the theta phase. In addition, we found reliable phase-phase coupling between theta and both gamma(S) and gamma(M) but not gamma(F) oscillators. We suggest that cross-frequency phase coupling can support multiple time-scale control of neuronal spikes within and across structures.
神经元振荡允许神经元尖峰的时间分割。相依振荡器可以整合多个信息层。我们在迷宫探索和快速眼动睡眠期间检查了大鼠海马 CA1 区的θ和γ振荡器的相位-相位耦合。海马θ波是不对称的，与传统的相位估计方法相比，通过识别基于波形的尖峰相位，可以提高对动物空间位置的估计。使用基于波形的θ相位，识别出三个不同的γ频段：慢γ（S）（γ（S）；30-50 Hz）、中频γ（M）（γ（M）；50-90 Hz）和快γ（F）（γ（F）；90-150 Hz 或 epsilon 带）。每个子带的振幅都受θ相位的调制。此外，我们发现θ和γ（S）和γ（M）振荡器之间存在可靠的相位-相位耦合，但γ（F）振荡器之间不存在。我们认为，跨频相位耦合可以支持在结构内和结构间对神经元尖峰进行多个时间尺度的控制。
