Solomon Richard
University of Vermont College of Medicine, USA; Fletcher Allen Health Care, USA.
J Cardiol. 2014 Jan;63(1):9-13. doi: 10.1016/j.jjcc.2013.10.001. Epub 2013 Nov 12.
Kidney injury following the administration of iodinated contrast media occurs particularly in patients with reduced kidney and cardiac function and when large doses of contrast are used. There is little compelling evidence that vasodilators and anti-oxidants prevent this injury. Most prevention trials have employed intravenous volume loading as a central strategy. However, the success of this approach depends upon maintaining euvolemia while producing a vigorous diuresis. A novel strategy for maintaining euvolemia and inducing a vigorous diuresis has been developed using the RenalGuard system. In this review; the mechanism of protective action is reviewed. The trials of the RenalGuard device are reviewed and future uses of the device are discussed.
使用碘化造影剂后发生的肾损伤尤其见于肾功能和心功能减退的患者以及使用大剂量造影剂时。几乎没有令人信服的证据表明血管扩张剂和抗氧化剂可预防这种损伤。大多数预防试验都采用静脉补液作为核心策略。然而，这种方法的成功取决于维持血容量正常的同时产生强力利尿作用。已开发出一种使用肾脏保护系统来维持血容量正常并诱导强力利尿的新策略。在本综述中，对其保护作用机制进行了回顾。对肾脏保护装置的试验进行了回顾，并讨论了该装置的未来用途。
