Crespi F
Neurosci Lett. 1986 May 6;66(1):1-6. doi: 10.1016/0304-3940(86)90156-4.
We have recently improved the technique of differential pulse voltammetry to detect extracellular 3,4-dihydroxyphenylacetic and 5-hydroxyindoleacetic acid concentrations in vivo with a single monopyrolytic carbon fibre electrode (working electrode). Thus it is now possible to perform a simultaneous evaluation of the turnover of dopamine (DA) and serotonin (5-HT) in a specific brain area of anaesthetized or conscious freely moving rats. We have attempted to determine whether there is an interaction between the two neuronal systems in the striatum. Our results show that various pharmacological manipulations in anaesthetized or conscious freely moving rats alter the activity of both systems suggesting the presence of interactions between 5-HT and DA systems in brain.
我们最近改进了差分脉冲伏安法技术，以使用单个热解碳纤维电极（工作电极）在体内检测细胞外3,4-二羟基苯乙酸和5-羟基吲哚乙酸的浓度。因此，现在可以同时评估麻醉或清醒自由活动大鼠特定脑区中多巴胺（DA）和5-羟色胺（5-HT）的代谢情况。我们试图确定纹状体中这两个神经元系统之间是否存在相互作用。我们的结果表明，对麻醉或清醒自由活动大鼠进行的各种药理学操作会改变这两个系统的活性，这表明大脑中5-HT和DA系统之间存在相互作用。
