解析素，一种专门的促解决脂质介质，及其在代谢性疾病中的潜在作用。
Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases.
机构信息
Diabetes and Obesity Center, Institute of Molecular Cardiology and Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.
Department of Biochemistry and Molecular Genetics, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Esther Koplowitz Biomedical Research Center, University of Barcelona, Barcelona 08036, Spain.
出版信息
Cell Metab. 2014 Jan 7;19(1):21-36. doi: 10.1016/j.cmet.2013.10.006. Epub 2013 Nov 14.
Inflammation is associated with the development of diseases characterized by altered nutrient metabolism. Although an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic diseases is sustained and detrimental. The resolution of inflammation involves the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling. Specialized proresolving lipid mediators (SPMs)-resolvins, protectins, and maresins-are novel autacoids that resolve inflammation, protect organs, and stimulate tissue regeneration. Here, we review evidence that the failure of resolution programs contributes to metabolic diseases and that SPMs may play pivotal roles in their resolution.
炎症与以改变营养代谢为特征的疾病的发展有关。虽然急性炎症反应对宿主具有保护作用，且通常是自我限制的，但与代谢疾病相关的慢性低度炎症则持续存在并具有危害性。炎症的消退涉及到中性粒细胞募集的终止、促炎介质的反向调节、巨噬细胞介导的清除的刺激和组织重塑。专门的促解决脂质介质（SPMs）- resolvins、 protectins 和maresins-是新型的自分泌物质，可解决炎症、保护器官并刺激组织再生。在这里，我们回顾了证据表明，解决程序的失败导致代谢疾病的发生，而 SPMs 可能在其解决中发挥关键作用。
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