Saqib Uzma, Pandey Monika, Vyas Anjali, Patidar Preeti, Hajela Sumati, Ali Asgar, Tiwari Meenakshi, Sarkar Sutripta, Yadav Neelam, Patel Shivani, Shukla Deepali, Lienemann Grace N, White Fletcher A, García-Perdomo Herney Andrés, Baig Mirza Saqib, Halade Ganesh V, Hajela Krishnan, Sharma Sadhana, Obukhov Alexander G
School of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road Campus, Indore 452001, Madhya Pradesh, India.
Dr. Vikram Sarabhai Institute of Cell and Molecular Biology, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Cells. 2025 Aug 12;14(16):1244. doi: 10.3390/cells14161244.
Lipoxins were discovered 40 years ago, and since then, their beneficial roles for human health have been confirmed in numerous studies. These small molecules belong to the eicosanoid class of compounds, which are generated metabolically by lipoxygenases. Lipoxins are released during various diseases and conditions, including but not limited to systemic inflammation, infection, asthma, cancer, diabetes, and cardiovascular disorders. Recently, several synthetic lipoxin analogs have been developed that also exhibit potent anti-inflammatory properties. In this review, we discuss the inflammation-resolving roles of lipoxins in various major diseases. Further, we summarize the latest reports on the use of synthetic lipoxins as potential therapeutic agents and discuss the role of aspirin-dependent lipoxin production in alleviating various diseases, including cancer.
脂氧素于40年前被发现，自那时起，它们对人类健康的有益作用在众多研究中得到了证实。这些小分子属于类花生酸类化合物，由脂氧合酶通过代谢产生。脂氧素在各种疾病和病症中释放，包括但不限于全身性炎症、感染、哮喘、癌症、糖尿病和心血管疾病。最近，已经开发出几种合成脂氧素类似物，它们也表现出强大的抗炎特性。在这篇综述中，我们讨论了脂氧素在各种主要疾病中的炎症消退作用。此外，我们总结了关于使用合成脂氧素作为潜在治疗剂的最新报告，并讨论了阿司匹林依赖性脂氧素产生在缓解包括癌症在内的各种疾病中的作用。
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