Department of Biology & Anatomy, New York Medical College, Valhalla, NY 10595, USA.
Department of Biology & Anatomy, New York Medical College, Valhalla, NY 10595, USA.
Life Sci. 2014 Jan 14;94(1):92-8. doi: 10.1016/j.lfs.2013.11.003. Epub 2013 Nov 14.
Although seizures are known to be harmful, recent evidence indicates that they can also lead to adaptations that protect neurons from further insult. For example, a history of two episodes of status epilepticus during a critical period of early development can prolong the time period of resistance to hippocampal injury during the postnatal period. Neonatal seizures may lead to this neuroprotection via a preconditioning mechanism that could be attributed to attenuation of Ca(2+) currents, reduction of inflammation, and induction of survival signaling pathways. Understanding mechanisms underlying neuroprotective preconditioning may elucidate new therapeutic targets and improve outcomes and quality of life for pediatric epilepsy patients. This review will detail the specific cellular and molecular findings involved in neuronal preconditioning predisposed by early-life seizures.
虽然众所周知癫痫发作是有害的，但最近的证据表明，它们也可以导致适应性变化，从而保护神经元免受进一步损伤。例如，在早期发育的关键时期发生两次癫痫持续状态的病史，可以延长出生后期间对海马损伤的抵抗时间。新生儿癫痫发作可能通过一种预处理机制导致这种神经保护作用，这种机制可能归因于钙（Ca(2+)）电流的衰减、炎症的减少和生存信号通路的诱导。了解神经保护预处理的机制可能阐明新的治疗靶点，并改善儿科癫痫患者的预后和生活质量。这篇综述将详细介绍由早期癫痫发作引起的神经元预处理所涉及的特定细胞和分子发现。
