维生素 D 缺乏症猪皮肤中的维生素 D 受体和 CD86 表达。
Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine.
机构信息
Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA.
Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA.
出版信息
Exp Mol Pathol. 2014 Feb;96(1):42-7. doi: 10.1016/j.yexmp.2013.11.002. Epub 2013 Nov 13.
The immunomodulatory role of vitamin D in many diseases is well established. However, the relationship between vitamin D status and skin cancers is unclear. In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melanoma skin cancers, our findings suggest a potential role of vitamin D-deficiency in the progression of skin malignancies.
维生素 D 在许多疾病中的免疫调节作用已得到充分证实。然而，维生素 D 状态与皮肤癌之间的关系尚不清楚。在这项研究中，我们研究了维生素 D 缺乏和充足对 Yucatan 微型猪 tragus 表皮中的 VDR、NF-κB 和 CD86 的影响。所有这些蛋白在黑色素瘤和非黑色素瘤皮肤癌等皮肤恶性肿瘤的发病机制中都有已知作用。与维生素 D 充足的猪相比，维生素 D 缺乏的猪表皮中 VDR 的核染色较弱且不明显，CD86 免疫反应较弱且呈斑驳的膜表达。NF-κB 的免疫染色没有差异。由于 VDR 和 CD86 的表达在黑色素瘤和非黑色素瘤皮肤癌中减少，我们的研究结果表明维生素 D 缺乏可能在皮肤恶性肿瘤的进展中起作用。
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