Fritzsch Claire, Wang Jing, Dos Santos Luara Ferreira, Mauritz Karl-Heinz, Brunetti Maddalena, Dohle Christian
MEDIAN Klinik Berlin-Kladow, Berlin, Germany Centre for Stroke Research Berlin, Charité - University Medicine Berlin, Berlin, Germany.
MEDIAN Klinik Berlin-Kladow, Berlin, Germany Department of Neurology, Charité - University Medicine Berlin, Berlin, Germany Centre of Rehabilitation, the Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Restor Neurol Neurosci. 2014;32(2):269-80. doi: 10.3233/RNN-130343.
Mirror therapy can improve motor and sensory functions, but effects of the mirror illusion on primary motor and somatosensory cortex could not be established consistently.
Fifteen right handed healthy volunteers performed or observed a finger-thumb opposition task. Cerebral activations during normal movement (NOR), mirrored movement (MIR) and movement observation (OBS) by means of a video chain were recorded with functional magnetic resonance imaging (fMRI). Activation sizes in movement > static conditions were identified using SPM8 (p < 0.001, unc.) and attributed to predefined areas employing the Anatomy toolbox 1.8. Laterality indices for the responsive areas were calculated on the basis of the number of activated voxels.
Relevant bilateral BOLD responses were found in primary motor (M1) and somatosensory (S1 - BA 2, 3b and 3a) cortex, premotor and parietal areas and V5. When comparing MIR to NOR, no significant change of contralateral activation in M1 was found, but clearly at S1 with differences between hands.
The mirror illusion does not elicit immediate changes in motor areas, yet there is a direct effect on somatosensory areas, especially for left hand movements. These results suggest different effects of mirror therapy on processing and rehabilitation of motor and sensory function.
镜像疗法可改善运动和感觉功能，但镜像错觉对初级运动皮层和躯体感觉皮层的影响尚未得到一致证实。
15名右利手健康志愿者执行或观察拇指对指任务。通过视频链记录正常运动（NOR）、镜像运动（MIR）和运动观察（OBS）期间的脑激活情况，采用功能磁共振成像（fMRI）。使用SPM8（p < 0.001，未校正）识别运动>静止条件下的激活大小，并使用解剖工具箱1.8将其归因于预定义区域。根据激活体素的数量计算反应区域的偏侧指数。
在初级运动皮层（M1）、躯体感觉皮层（S1 - BA 2、3b和3a）、运动前区、顶叶区域和V5区发现了相关的双侧BOLD反应。将MIR与NOR进行比较时，未发现M1区对侧激活有显著变化，但在S1区明显存在双手差异。
镜像错觉不会立即引起运动区域的变化，但对躯体感觉区域有直接影响，尤其是左手运动。这些结果表明镜像疗法对运动和感觉功能的处理及康复有不同影响。
