Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Children's Research Institute, University of South Florida, 140-7th Avenue South, Box 7890, St. Petersburg, FL, 33701, USA.
J Clin Immunol. 2014 Jan;34(1):49-52. doi: 10.1007/s10875-013-9968-0. Epub 2013 Nov 16.
Sporothrix schenckii lymphadenitis was identified in a 33 month old male with X-linked chronic granulomatous disease (CGD). S. schenckii is a dimorphic catalase producing fungus found in the soil of temperate and tropical climates. Host defense against S. schenckii relies primarily on innate and cellular responses and gp91(phox-/-) mice are susceptible to disseminated infection. This case represents the first report of susceptibility to sporotrichosis in a patient with CGD.
33 个月大的男性 X 连锁慢性肉芽肿病（CGD）患者被诊断患有申克孢子丝菌淋巴结炎。申克孢子丝菌是一种在温带和热带土壤中发现的产过氧化氢酶的双相真菌。宿主对申克孢子丝菌的防御主要依赖于先天和细胞反应，gp91(phox-/-) 小鼠易发生播散性感染。本病例是首例 CGD 患者对孢子丝菌病易感性的报告。
