Wallengren J, Ekman R, Möller H
Acta Derm Venereol. 1986;66(1):23-8.
Immunoreactivity (IR) of substance P (SP) and Vasoactive Intestinal Peptide (VIP) were determined by radioimmunoassay in serum of 56 patients with inflammatory skin diseases, in blister fluid of 40 patients with spontaneous blisters and 31 subjects with induced skin blisters. Serum concentrations of SP-IR and VIP-IR were mostly low or non-detectable. Spontaneous blisters contained high amounts of SP-IR, particularly in bullous pemphigoid and in some inflammatory dermatoses, while VIP-IR levels usually were low. Suction blisters from inflamed but not from normal skin often contained SP-IR but more seldom VIP-IR.
采用放射免疫分析法测定了56例炎症性皮肤病患者血清、40例自发性水疱患者疱液以及31例诱发性皮肤水疱患者疱液中P物质（SP）和血管活性肠肽（VIP）的免疫反应性（IR）。SP-IR和VIP-IR的血清浓度大多较低或无法检测到。自发性水疱中含有大量的SP-IR，尤其是在大疱性类天疱疮和一些炎症性皮肤病中，而VIP-IR水平通常较低。来自发炎皮肤而非正常皮肤的抽吸疱液中常含有SP-IR，但很少含有VIP-IR。
