[免疫调节剂对辐射损伤淋巴细胞淋巴因子分泌的影响]
[The influence of immunomodulators on lymphokine secretion of radiation-damaged lymphocytes].
作者信息
Kowalczyk-Bronisz S H, Paegelow I
出版信息
Allerg Immunol (Leipz). 1986;32(1):57-64.
Spleen lymphocytes derived from guinea pigs loose their ability to secrete lymphokines induced by Con A after treatment with irradiation (500 and 750 mC/kg). In the presence of the immunomodulator isoprinosine, levamisole and the thymosine-like factor TFX the lymphocytes are again capable of secreting lymphokines. After treatment with isoprinosine, levamisole and TFX in dosages between 10 and 100 micrograms/ml the migration inhibition activity for macrophages and the chemotactic activity for polymorphonuclear granulocytes produced by lymphocytes were restored.
来自豚鼠的脾淋巴细胞在接受辐射（500和750 mC/kg）处理后，失去了分泌由刀豆蛋白A诱导的淋巴因子的能力。在免疫调节剂异丙肌苷、左旋咪唑和胸腺素样因子TFX存在的情况下，淋巴细胞再次能够分泌淋巴因子。用10至100微克/毫升剂量的异丙肌苷、左旋咪唑和TFX处理后，淋巴细胞产生的对巨噬细胞的迁移抑制活性和对多形核粒细胞的趋化活性得以恢复。
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