Hadden J W
Cancer Treat Rep. 1978 Nov;62(11):1981-5.
Four immunopotentiators, levamisole, isoprinosine, muramyl dipeptide, and SM1213, were analyzed in vitro for their effect on phytohemagglutinin-induced lymphocyte proliferation and lymphokine-induced macrophage proliferation and activation to kill Listeria monocytogenes. Isoprinosine augmented all three functions. Levamisole augmented lymphocyte proliferation and lymphokine-induced macrophage activation. Muramyl dipeptide and SM1213 induced macrophage activation directly. The effects of these agents on these cells at concentrations relevant to in vivo therapy support their immunopharmacologic application to modify cellular immunity.
对四种免疫增强剂，即左旋咪唑、异丙肌苷、胞壁酰二肽和SM1213进行了体外分析，以研究它们对植物血凝素诱导的淋巴细胞增殖、淋巴因子诱导的巨噬细胞增殖以及巨噬细胞激活以杀灭单核细胞增生李斯特菌的影响。异丙肌苷增强了所有这三种功能。左旋咪唑增强了淋巴细胞增殖和淋巴因子诱导的巨噬细胞激活。胞壁酰二肽和SM1213直接诱导巨噬细胞激活。这些药物在与体内治疗相关的浓度下对这些细胞的作用支持了它们在调节细胞免疫方面的免疫药理学应用。
