i3 Institute, School of Medical and Molecular Sciences, University of Technology, Sydney, Ultimo, NSW, Australia.
Department of Microbiology, SydPath, St Vincent's Hospital, Victoria St., Darlinghurst, NSW, Australia.
J Med Microbiol. 2014 Feb;63(Pt 2):252-257. doi: 10.1099/jmm.0.065508-0. Epub 2013 Nov 15.
This article reports long-term infection and treatment failure in 18 symptomatic individuals infected with Blastocystis spp. Patients were initially treated with either metronidazole, iodoquinol or triple combination therapy consisting of nitazoxanide, furazolidone and secnidazole. Following treatment, resolution of clinical symptoms did not occur and follow-up testing revealed ongoing infection with the same subtype. Patients then underwent secondary treatment with a variety of antimicrobial agents but remained symptomatic with Blastocystis spp. still present in faeces. Sequencing of the SSU rDNA was completed on all isolates and four subtypes were identified in this group: ST1, ST3, ST4 and ST5. This study highlights the lack of efficacy of several commonly used antimicrobial regimens in the treatment of Blastocystis and the chronic nature of some infections. It also demonstrates the need for further research into treatment options for Blastocystis infection.
本文报道了 18 例有症状的 Blastocystis spp. 感染患者的长期感染和治疗失败。患者最初接受甲硝唑、碘喹啉或硝唑尼特、呋喃唑酮和塞克硝唑三联疗法治疗。治疗后，临床症状并未缓解，随访检测显示仍存在同种亚型感染。随后，患者接受了多种抗菌药物的二线治疗，但仍有 Blastocystis spp. 相关症状，粪便中仍存在该病原体。对所有分离株进行了 SSU rDNA 测序，在该组中鉴定出了 4 种亚型：ST1、ST3、ST4 和 ST5。本研究强调了几种常用抗菌方案治疗 Blastocystis 的疗效不足，以及一些感染的慢性性质。它还表明需要进一步研究 Blastocystis 感染的治疗选择。
