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黎巴嫩地区内肠贾第虫的分子流行病学研究及其亚型 1 与胃肠道症状之间的相关性。

Molecular epidemiology of Blastocystis in Lebanon and correlation between subtype 1 and gastrointestinal symptoms.

机构信息

Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille, Inserm U1019, CNRS UMR 8204, Université Lille Nord de France, EA4547, Lille, France.

出版信息

Am J Trop Med Hyg. 2013 Jun;88(6):1203-6. doi: 10.4269/ajtmh.12-0777. Epub 2013 Mar 4.

DOI:10.4269/ajtmh.12-0777
PMID:23458955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3752823/
Abstract

Blastocystis is the most common eukaryotic parasite in the intestinal tract of humans. Because of its potential impact in public health, we acquired the first data concerning the prevalence of this parasite and the frequency of the Blastocystis subtypes (STs) in the Lebanese population. In this study, fecal samples from 220 Lebanese symptomatic and asymptomatic patients were collected and a total of 42 patients (19%) were identified as positive for this parasite by direct-light microscopy of smears. Among these, 36 Blastocystis isolates were genotyped using partial small subunit ribosomal RNA gene sequencing. The ST distribution in the present Lebanese population was as follows: ST3 (33.3%), ST2 (33.3%), ST1 (30.6%), and ST4 (2.8%). These data were compared with those available in other Middle Eastern and neighboring countries. Finally, ST1 was significantly more prevalent among symptomatic patients of this Lebanese population.

摘要

芽囊原虫是人类肠道中最常见的真核寄生虫。由于其对公共卫生的潜在影响,我们获得了有关该寄生虫在黎巴嫩人群中的流行率和芽囊原虫亚型(ST)频率的首批数据。在这项研究中,收集了 220 名黎巴嫩有症状和无症状患者的粪便样本,通过涂片直接显微镜检查,共有 42 名患者(19%)被确定为该寄生虫阳性。其中,36 个芽囊原虫分离株通过部分小亚基核糖体 RNA 基因测序进行了基因分型。目前黎巴嫩人群中的 ST 分布如下:ST3(33.3%)、ST2(33.3%)、ST1(30.6%)和 ST4(2.8%)。这些数据与其他中东和邻国的数据进行了比较。最后,在这个黎巴嫩人群中,ST1 在有症状的患者中更为普遍。

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