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用于脑膜炎奈瑟菌的实验性多血清群疫苗的研发。

The development of an experimental multiple serogroups vaccine for Neisseria meningitidis.

作者信息

Pinto Valerian B, Burden Robert, Wagner Allyn, Moran Elizabeth E, Lee Che-Hung

机构信息

Division of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research (WRAIR), Silver Springs, Maryland, United States of America.

出版信息

PLoS One. 2013 Nov 14;8(11):e79304. doi: 10.1371/journal.pone.0079304. eCollection 2013.

DOI:10.1371/journal.pone.0079304
PMID:24244473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3828347/
Abstract

A native outer membrane vesicles (NOMV) vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide (LOS) immunotypes, and whose synX, and lpxL1 genes were deleted.. Immunogenicity studies in mice showed that the vaccine induced bactericidal antibody against serogroups B, C, W, Y and X N. meningitidis strains. However, this experimental NOMV vaccine was not effective against serogroup A N. meningitidis strains. N. meningitidis capsular polysaccharide (PS) from serogroups A, C, W and Y were effective at inducing bactericidal antibody when conjugated to either tetanus toxoid or the fHbp1-fHbp2 fusion protein fHbp(1+2). The combination of the NOMV vaccine and the N. meningitidis serogroup A capsular polysaccharide (MAPS) protein conjugate was capable of inducing bactericidal antibodies against a limited number of N. meningitidis strains from serogroups A, B, C, W, Y and X tested in this study.

摘要

一种天然外膜囊泡（NOMV）疫苗是由三种抗原性不同的脑膜炎奈瑟菌菌株研制而成，这些菌株表达L1,8、L2和L3,7脂寡糖（LOS）免疫型，且其synX和lpxL1基因已被删除。在小鼠身上进行的免疫原性研究表明，该疫苗可诱导针对B、C、W、Y和X血清群脑膜炎奈瑟菌菌株的杀菌抗体。然而，这种实验性NOMV疫苗对A血清群脑膜炎奈瑟菌菌株无效。当A、C、W和Y血清群的脑膜炎奈瑟菌荚膜多糖（PS）与破伤风类毒素或fHbp1 - fHbp2融合蛋白fHbp(1+2)偶联时，能有效诱导杀菌抗体。NOMV疫苗与A血清群脑膜炎奈瑟菌荚膜多糖（MAPS）蛋白偶联物的组合能够诱导针对本研究中测试的A、B、C、W、Y和X血清群有限数量的脑膜炎奈瑟菌菌株的杀菌抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/4ecf7b0716a8/pone.0079304.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/e10e61223cda/pone.0079304.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/ceec221025dd/pone.0079304.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/811d8675188a/pone.0079304.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/097d3fddcc62/pone.0079304.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/86c5cf0bfb68/pone.0079304.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/4ecf7b0716a8/pone.0079304.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/e10e61223cda/pone.0079304.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/ceec221025dd/pone.0079304.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/811d8675188a/pone.0079304.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/097d3fddcc62/pone.0079304.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/86c5cf0bfb68/pone.0079304.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/361d/3828347/4ecf7b0716a8/pone.0079304.g006.jpg

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