Mestecky J, Russell M W, Jackson S, Brown T A
Clin Immunol Immunopathol. 1986 Jul;40(1):105-14. doi: 10.1016/0090-1229(86)90073-5.
In healthy adults the total daily production of secretory and serum IgA exceeds that of other immunoglobulin classes. Secretory and serum IgA display features of mutual independence: they are represented by molecules with different physiochemical and immunochemical properties and antibody activities and are produced by cells with different organ distributions. Secretory and serum IgA also exhibit different effector functions: interaction of secretory IgA with environmental antigens results in prevention of the penetration of such antigens by a variety of mechanisms. Although the function of polymeric serum IgA antibodies in certain animal species involves elimination of antigenic substances by noninflammatory means, the primary function of serum IgA remains unknown. It is proposed that in humans monomeric serum IgA (which prevents activation of the complement systems, inhibits phagocytosis and antibody-dependent cellular cytotoxicity) may protect endogenous antigens expressed on various cells and tissues by preventing their interaction with humoral and cellular immune mechanisms that may lead to tissue damage.
在健康成年人中，分泌型和血清型IgA的每日总产量超过其他免疫球蛋白类别。分泌型和血清型IgA表现出相互独立的特征：它们由具有不同理化和免疫化学性质以及抗体活性的分子代表，并由具有不同器官分布的细胞产生。分泌型和血清型IgA还表现出不同的效应功能：分泌型IgA与环境抗原的相互作用通过多种机制防止此类抗原的渗透。尽管某些动物物种中聚合血清IgA抗体的功能涉及通过非炎症方式消除抗原物质，但血清IgA的主要功能仍然未知。有人提出，在人类中，单体血清IgA（可防止补体系统激活，抑制吞噬作用和抗体依赖性细胞毒性）可能通过防止内源性抗原与可能导致组织损伤的体液和细胞免疫机制相互作用，从而保护在各种细胞和组织上表达的内源性抗原。
