Mestecky J, Czerkinsky C, Russell M W, Brown T A, Prince S J, Moldoveanu Z, Jackson S, Michalek S M, McGhee J R
Department of Microbiology, University of Alabama, Birmingham 35294.
Ann Allergy. 1987 Nov;59(5 Pt 2):54-9.
A generalized secretory IgA response can be induced by ingestion of various antigens due to dissemination of sensitized precursors of IgA plasma cells from gut-associated lymphoid tissue to various secretory glands. Oral ingestion of a bacterial antigen by volunteers led to the parallel appearance of secretory IgA antibodies in several external secretions that was preceded by a transitory detection of IgA antibody-secreting cells in the peripheral blood. Naturally occurring secretory and serum IgA antibodies as well as secretory and serum antibodies induced by mucosal immunization belong predominantly to the IgA1 subclass; however, in external secretions IgA2 is the predominant subclass of natural antibodies to endotoxin and lipoteichoic acid. Although in external secretions specific IgA antibodies are of polymeric form, serum IgA antibodies to different antigens display considerable variability with respect to their distribution in polymeric and monomeric forms. However, after experimental infection, serum IgA antibodies to the influenza virus hemagglutinin are almost exclusively polymeric.
由于IgA浆细胞的致敏前体从肠道相关淋巴组织扩散到各种分泌腺，摄入各种抗原可诱导全身性分泌型IgA反应。志愿者口服细菌抗原后，几种外分泌液中同时出现分泌型IgA抗体，在外周血中短暂检测到IgA抗体分泌细胞之后。天然存在的分泌型和血清型IgA抗体以及黏膜免疫诱导的分泌型和血清型抗体主要属于IgA1亚类；然而，在外分泌液中，IgA2是针对内毒素和脂磷壁酸的天然抗体的主要亚类。尽管在外分泌液中特异性IgA抗体为多聚体形式，但针对不同抗原的血清IgA抗体在其多聚体和单体形式的分布方面表现出相当大的变异性。然而，实验感染后，针对流感病毒血凝素的血清IgA抗体几乎完全是多聚体。
