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Overcoming resistance against HER2-targeting agents in fifth-line therapy: is there still a place for bevacizumab in HER2+ breast cancer?

作者信息

Huemer Florian, Gampenrieder Simon Peter, Schlattau Alexander, Greil Richard

机构信息

Third Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute with Laboratory of Immunological and Molecular Cancer Research and Center for Clinical Cancer and Immunology Trials, Paracelsus Medical University Salzburg, Salzburg, Austria.

Department of Radiology, Paracelsus Medical University Salzburg, Salzburg, Austria.

出版信息

Clin Breast Cancer. 2014 Feb;14(1):e17-20. doi: 10.1016/j.clbc.2013.09.009. Epub 2013 Sep 28.

DOI:10.1016/j.clbc.2013.09.009
PMID:24246725
Abstract
摘要

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Squalamine blocks tumor-associated angiogenesis and growth of human breast cancer cells with or without HER-2/neu overexpression.鲨肝醇抑制肿瘤相关血管生成和 HER-2/neu 过表达或不表达的人乳腺癌细胞的生长。
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