Soler Monsó M T, Català I, Terricabras M, Petit A, Climent F, Pérez-Casanovas L, Gumà A, Morilla I
Department of Pathology, Hospital Universitari de Bellvitge/IDIBELL, Barcelona, Spain.
Acta Cytol. 2014;58(1):9-14. doi: 10.1159/000354383. Epub 2013 Nov 15.
Metaplastic carcinoma with chondroid differentiation (MMPC) is a subtype of breast metaplastic carcinoma with mesenchymal differentiation. Although fine-needle aspiration (FNAB) and core-needle biopsy (CNB) are commonly used for the diagnosis of breast cancer, not enough studies proving the diagnostic cost-effectiveness of these techniques for the identification of MMPC have been published so far. The aim of this study was to investigate the concordance between the presurgical diagnosis using FNAB/CNB and the definitive diagnosis in the surgical specimen in pure MMPC. A case of MMPC is also reported.
All cases of MMPC diagnosed in our institution from 1995 to 2011 were reviewed. The presence of chondroid differentiation in cytological studies or biopsies and the proportion of chondroid matrix in the surgical specimen were evaluated.
A total of 13 cases of pure MMPC were collected. The diagnosis was suspected in 25% of FNABs and was rendered in 40% of CNBs.
The chondroid component in MMPC is hard to identify by FNAB and CNB. The random distribution and proportion of the chondroid differentiation in the tumour and the expertise in performing the technique and in identifying the chondroid component may play an important role in the diagnosis of MMPC using these techniques.
具有软骨样分化的化生癌（MMPC）是乳腺间叶分化化生癌的一种亚型。尽管细针穿刺抽吸活检（FNAB）和粗针穿刺活检（CNB）常用于乳腺癌的诊断，但目前尚未发表足够的研究来证明这些技术对MMPC诊断的成本效益。本研究的目的是调查在纯MMPC中，使用FNAB/CNB进行术前诊断与手术标本最终诊断之间的一致性。本文还报告了1例MMPC病例。
回顾了1995年至2011年在本机构诊断的所有MMPC病例。评估了细胞学研究或活检中软骨样分化的存在情况以及手术标本中软骨样基质的比例。
共收集到13例纯MMPC病例。25%的FNAB怀疑有诊断，40%的CNB做出了诊断。
MMPC中的软骨样成分很难通过FNAB和CNB识别。肿瘤中软骨样分化的随机分布和比例以及实施该技术和识别软骨样成分的专业知识可能在使用这些技术诊断MMPC中起重要作用。
