Davey D D, Glant M D, Berger E K
Diagn Cytopathol. 1986 Jan-Mar;2(1):76-80. doi: 10.1002/dc.2840020116.
Cytologic criteria for diagnosing parathyroid adenomas and hyperplasia have not been elucidated. This report will present the cytomorphology of parathyroid tissue in the spectrum of normal, hyperplastic, and neoplastic states. We examined clinical needle aspirates from three patients with parathyroid lesions as well as 15 needle aspirations or touch preparations from surgical specimens. The series included three with hyperparathyroidism secondary to chronic renal failure, four with primary chief cell hyperplasia, nine with typical adenomas, and two with atypical adenomas. Normal parathyroid glands were also studied. Most parathyroid lesions could be distinguished from thyroid lesions by frequent thick fragments of cohesive cells with frayed edges and typical nuclear features. In general, the nuclei were small (6-8 mu) and round with regular coarse granular chromatin. Occasional larger nuclei (10-30 mu) with similar chromatin were observed in some cases. Oxyphil cells with abundant granular cytoplasm were present in some cases; one case with mostly oxyphil cells was difficult to differentiate from a thyroid neoplasm. Pseudocolloid was found in seven cases. Criteria for the differentiation between parathyroid hyperplasia and adenomas were not discovered. In addition, the cytology and differential diagnosis of atypical parathyroid adenomas are described and illustrated.
用于诊断甲状旁腺腺瘤和增生的细胞学标准尚未阐明。本报告将呈现甲状旁腺组织在正常、增生和肿瘤状态下的细胞形态学。我们检查了3例甲状旁腺病变患者的临床针吸标本以及15例手术标本的针吸或印片标本。该系列包括3例继发于慢性肾衰竭的甲状旁腺功能亢进患者、4例原发性主细胞增生患者、9例典型腺瘤患者和2例非典型腺瘤患者。还对正常甲状旁腺进行了研究。大多数甲状旁腺病变可通过常见的具有参差不齐边缘的紧密细胞厚片段和典型的核特征与甲状腺病变相区分。一般来说，细胞核小（6 - 8微米），圆形，染色质粗糙且规则。在某些情况下，偶尔会观察到一些具有相似染色质的较大细胞核（10 - 30微米）。部分病例中可见具有丰富颗粒状胞质的嗜酸性细胞；1例主要为嗜酸性细胞的病例难以与甲状腺肿瘤区分。7例中发现了假胶体。未发现甲状旁腺增生与腺瘤鉴别的标准。此外，还对非典型甲状旁腺腺瘤的细胞学及鉴别诊断进行了描述和说明。
