Morere J F, Israel L, Breau J L, Clavier J, Guillerm D, Zabbe C, Raut Y, Morere P, Nouvet G, Lerebours Pigeonniere G
Drugs Exp Clin Res. 1985;11(3):233-5.
Palliative chemotherapy in cases of epidermoid bronchogenic carcinoma, initially judged to be inoperable, made it possible to perform operative resection in 50 cases. An association of cis-platinum and bleomycin was used, this combination having previously been considered synergistic. In certain cases the tumour seemed to have disappeared on macroscopic examination of the resected specimen, and in some instances no tumoral cells could be found on histological examination. This series brought out several positive features: chemotherapy made it possible to operate on patients previously judged to be inoperable; it ensured maximum local efficiency of drugs because of the absence of abnormal vascularity; and it made it possible to anticipate the cure of occult metastases. However, three negative aspects were also present: modification of postoperative TNM classification making it difficult to establish a prognosis; difficulty in determining therapeutic strategy for pNo; and inadequate long-term follow-up. On the whole the positive points appeared to outweigh the negative aspects, but a randomized study is necessary to confirm this.
对于最初判定为无法手术的表皮样支气管癌病例，姑息化疗使50例患者能够进行手术切除。采用了顺铂和博来霉素联合用药，此前认为这种联合具有协同作用。在某些病例中，切除标本的宏观检查显示肿瘤似乎已消失，在一些情况下，组织学检查未发现肿瘤细胞。该系列研究呈现出几个积极特征：化疗使先前判定为无法手术的患者能够接受手术；由于不存在异常血管，确保了药物的最大局部疗效；并且能够预见隐匿性转移灶的治愈情况。然而，也存在三个消极方面：术后TNM分类的改变使得难以建立预后；确定pNo的治疗策略存在困难；以及长期随访不足。总体而言，积极方面似乎超过消极方面，但需要进行随机研究来证实这一点。
