Quoix E, Pelletier A, Schaller M, Pillement P, Dietemann-Molard A, Klein T, Spielmann P, Orion B, Chaix C
Rev Pneumol Clin. 1984;40(2):127-9.
Inoperable non- microcellular primary bronchial carcinomas have been reputed up to now to be chemo-resistant. The introduction of Cis-platinum into a polychemotherapy protocol leads to revision of this concept. The authors report the preliminary results of a polychemotherapy protocol (including Cis-platinum, Vindesine, CCNU, Cyclophosphamide) associated, in cases of non- metastasized carcinomas, with radiotherapy to the tumour itself, the mediastinum and the supraclavicular fossae. These results confirmed the value of such chemotherapy in forms with metastases. In localised inoperable forms, conclusions could be reached only on the basis of a randomised comparative trial of chemotherapy + radiotherapy versus radiotherapy alone.
迄今为止，无法手术的非微细胞原发性支气管癌一直被认为对化疗耐药。顺铂引入多药化疗方案后，这一观念得以修正。作者报告了一种多药化疗方案（包括顺铂、长春地辛、洛莫司汀、环磷酰胺）的初步结果，对于非转移性癌，该方案联合对肿瘤本身、纵隔和锁骨上窝进行放疗。这些结果证实了这种化疗在转移性癌中的价值。对于局部无法手术的癌，只有在化疗 + 放疗与单纯放疗的随机对照试验基础上才能得出结论。
