Department of Microbiology, Harbin Medical University, Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin, 150081, China.
Arch Virol. 2014 May;159(5):1027-32. doi: 10.1007/s00705-013-1886-1. Epub 2013 Nov 19.
This study aimed to investigate the overall prevalence of human papillomavirus (HPV) infection among women examined at a hospital in Harbin and to evaluate the impact of HPV types on the natural outcome and state of cervical cytology. A total of 2,938 female outpatients from the affiliated hospital of Harbin Medical University were enrolled. Rapid hybridization gene chip and liquid-based cytology tests were used to detect HPV genotypes and cervical cytology. The overall prevalence of HPV in women who came to this hospital was 36.45 %. The majority were infected with a single strain, and the high-risk HPV (HR-HPV) type constituted the largest proportion. HPV16 and 58 were the most common types, while the genotypes of single low-risk HPV (LR-HPV) were not the same in different age groups. HPV53, 16 and 81 were the most common types in multiple HR-HPV infection; HR-HPV16, 33, 81 and LR-HPV 6, 44, 43 were the most common in HR and LR-HPV infection. In total, 44.1 % of the women with HSIL and 44.0 % with ASCUS were positive for HR-HPV16. Multiple HPV infections and single HPV infections had no effect on the natural outcome after half a year. HPV16, 81 and 35 had a better natural outcome, followed by HPV52 and 53, but HPV58, 59 and 18 had a bad outcome after half a year. This is the first study to show that the distribution of HPV types is different in Harbin than it is in other regions. These findings will provide guidance for the vaccination program in this area.
本研究旨在调查哈尔滨某医院就诊女性人群中人类乳头瘤病毒（HPV）感染的总体流行率，并评估 HPV 型别对宫颈细胞学自然转归和状态的影响。共纳入哈尔滨医科大学附属医院 2938 例女性门诊患者。采用快速杂交基因芯片法和液基细胞学检测技术检测 HPV 基因型和宫颈细胞学。来该院就诊的女性 HPV 总感染率为 36.45%。多数为单一型别感染，高危型 HPV（HR-HPV）型别构成比例最大。HPV16 和 58 是最常见的型别，而不同年龄组单一低危型 HPV（LR-HPV）的基因型并不相同。HPV53、16 和 81 是多重 HR-HPV 感染中最常见的型别；HR-HPV16、33、81 和 LR-HPV6、44、43 是 HR 和 LR-HPV 混合感染中最常见的型别。HSIL 组和 ASCUS 组中，HR-HPV16 的阳性率分别为 44.1%和 44.0%。HPV16、81 和 35 型 HPV 混合感染和单一 HPV 感染对半年后的自然转归均无影响。HPV16、81 和 35 型 HPV 混合感染后自然转归较好，其次为 HPV52 和 53，但 HPV58、59 和 18 型 HPV 混合感染后半年转归较差。这是首次报道哈尔滨地区 HPV 型别分布与其他地区不同，为该地区的疫苗接种计划提供了指导。
