Wu Conglian, Zhu Xianjin, Kang Yanli, Cao Yinping, Lu Pingxia, Zhou Wenjuan, Zhou Hong, Zhang Yang, Song Yanfang
Department of Laboratory Medicine, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, 350001, China.
Department of Laboratory Medicine, The First Hospital of Quanzhou Affiliated to Fujian Medical University, 248-252 East Street, Quanzhou, Fujian, 362000, China.
BMC Public Health. 2017 Aug 3;18(1):95. doi: 10.1186/s12889-017-4651-7.
Human papillomavirus (HPV) infection is the main etiological factor for the development of cervical cancer. Here we assessed the prevalence and distribution of HPV genotypes in Fujian population.
A total of 8678 women aging from 17 to 84 years olds were recruited from the Fujian Medical University Union Hospital in Fujian Province. Every woman had a face-to-face interview. Cervical samples were collected from each participant and HPV screening was conducted using microarray hybridization.
Our study showed that the HPV prevalence in Fujian province was 38.3%. Among the positive individuals, 70.6% were detected for single HPV infection, 29.4% for multiple HPV infections. Further analysis showed that the prevalence of HPV infection significantly increased from 2009 to 2015. The four most common high risk human papillomavirus (HR-HPV) genotypes were HPV16 (8.5%), HPV52 (7.9%), HPV58 (6.2%), HPV 53 (3.5%), collectively accounting for 60.5% of all detected HPV infection. Age subgroup analysis showed two peaks for the frequencies of overall and multiple HPV infections, one for the group of women under 25 years old, and the other for the group over 55 years old.
HPV infection is becoming serious in Fujian province, which indicates the imperative to implement a HPV vaccination and screening program for this region.
人乳头瘤病毒（HPV）感染是宫颈癌发生的主要病因。在此，我们评估了福建省人群中HPV基因型的流行情况和分布。
从福建省福建医科大学附属协和医院招募了8678名年龄在17至84岁之间的女性。每位女性都进行了面对面访谈。从每位参与者采集宫颈样本，并使用微阵列杂交进行HPV筛查。
我们的研究表明，福建省HPV感染率为38.3%。在阳性个体中，70.6%检测为单一HPV感染，29.4%为多重HPV感染。进一步分析表明，2009年至2015年期间HPV感染率显著上升。四种最常见的高危人乳头瘤病毒（HR-HPV）基因型为HPV16（8.5%）、HPV52（7.9%）、HPV58（6.2%）、HPV53（3.5%），共占所有检测到的HPV感染的60.5%。年龄亚组分析显示，总体和多重HPV感染频率有两个高峰，一个在25岁以下女性组，另一个在55岁以上女性组。
HPV感染在福建省正变得严重，这表明该地区实施HPV疫苗接种和筛查计划势在必行。
