Katsura Masaki, Suzuki Yuichi, Hata Junichi, Hori Masaaki, Sasaki Hiroki, Akai Hiroyuki, Mori Harushi, Kunimatsu Akira, Masutani Yoshitaka, Aoki Shigeki, Ohtomo Kuni
Department of Radiology Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
J Magn Reson Imaging. 2014 Nov;40(5):1208-14. doi: 10.1002/jmri.24459. Epub 2013 Nov 19.
To investigate the use of non-Gaussian diffusion-weighted imaging (q-space imaging [QSI]) to estimate diurnal changes in intervertebral disc (IVD) microstructure.
IVDs of 15 male subjects (mean age, 27.3 years; mean body mass index, 22.50 kg/m(2) ) were investigated once in the morning, less than 30 min after rising, and a second time in the evening after at least 10 h of normal physical activity, using 3 Tesla (T) MR imaging. T2 mapping and QSI data values (apparent diffusion coefficient [ADC], root mean square displacement [RMSD], and apparent kurtosis coefficient [AKC]) were calculated and compared between the morning and evening imaging sessions.
The T2, ADC, and RMSD values showed a significant decrease in the evening (175.8 ± 49.5 ms, 1.56 ± 0.32 10(-3) mm(2) /s and 40.0 ± 3.0 μm, respectively; P < 0.05 for all values; paired t-test), when compared with the morning values (226.5 ± 83.8 ms, 1.69 ± 0.29 10(-3) mm(2) /s and 45.2 ± 2.9 μm, respectively). The AKC value showed a significant increase in the evening (0.67 ± 0.08), when compared with the morning value (0.58 ± 0.04; P < 0.05).
The RMSD and AKC values obtained from QSI analysis may be biomarkers for IVD diurnal microstructural changes.
研究使用非高斯扩散加权成像（q空间成像[QSI]）来估计椎间盘（IVD）微观结构的昼夜变化。
对15名男性受试者（平均年龄27.3岁；平均体重指数22.50kg/m²）的IVD进行研究，一次在早晨起床后不到30分钟进行，另一次在晚上经过至少10小时正常体力活动后进行，使用3特斯拉（T）磁共振成像。计算并比较早晨和晚上成像时段的T2映射和QSI数据值（表观扩散系数[ADC]、均方根位移[RMSD]和表观峰度系数[AKC]）。
与早晨的值（分别为226.5±83.8ms、1.69±0.29×10⁻³mm²/s和45.2±2.9μm）相比，晚上的T2、ADC和RMSD值显著降低（分别为175.8±49.5ms、1.56±0.32×10⁻³mm²/s和40.0±3.0μm；所有值P<0.05；配对t检验）。与早晨的值（0.58±0.04）相比，晚上的AKC值显著增加（0.67±0.08；P<0.05）。
从QSI分析获得的RMSD和AKC值可能是IVD昼夜微观结构变化的生物标志物。
