Conte V, Colautti P, Moro D, Grosswendt B
LNL-INFN, viale dell'Università 2, Legnaro I-35020, Italy
LNL-INFN, viale dell'Università 2, Legnaro I-35020, Italy.
Radiat Prot Dosimetry. 2014 Oct;161(1-4):445-8. doi: 10.1093/rpd/nct266. Epub 2013 Nov 17.
The likelihood of radiation to produce clustered damages in irradiated biological tissue and the reparability of such damages are closely related to the stochastics of localised ionising interactions within small volumes of nanometre sizes, determined by the particle track structure. Track structure investigations in nanometre-sized volumes have been subject of research for several decades, mainly by means of Monte Carlo simulations. Today, the 'track-nanodosimeter', installed at the TANDEM-ALPI accelerator complex of LNL, is a measuring device able to count the electrons produced in a 20-nm equivalent sensitive site (De Nardo et al. A detector for track-nanodosimetry. Nucl. Instrum. Methods. Phys. Res. A 484: , 312-326 (2002)). It allows studying track structure properties both in the near neighbourhood of a primary particle trajectory and separately in the penumbra region. An extended study for different ionising particles of medical interest has been recently performed with the track-nanodosimeter (Conte et al. Track structure of light ions: experiments and simulations. New J. Phys. 14: , 093010, (2012)). Here, new experimental data and results of Monte Carlo simulations for 240- and 96-MeV (12)C-ions are presented and discussed.
辐射在受辐照生物组织中产生簇状损伤的可能性以及此类损伤的可修复性，与由粒子径迹结构决定的纳米级小体积内局部电离相互作用的随机性密切相关。几十年来，纳米级体积内的径迹结构研究一直是研究的主题，主要通过蒙特卡罗模拟进行。如今，安装在LNL的串联ALPI加速器装置上的“径迹纳米剂量仪”是一种能够对在20纳米等效敏感位点产生的电子进行计数的测量设备（德纳尔迪等人，《径迹纳米剂量测量的探测器》，《核仪器与方法：物理研究A》第484卷，第312 - 326页（2002年））。它既可以研究初级粒子轨迹附近的径迹结构特性，也可以单独研究半影区的径迹结构特性。最近使用径迹纳米剂量仪对不同的具有医学意义的电离粒子进行了扩展研究（孔特等人，《轻离子的径迹结构：实验与模拟》，《新物理学杂志》第14卷，第093010期，（2012年））。在此，给出并讨论了240兆电子伏和96兆电子伏碳 - 12离子的新实验数据和蒙特卡罗模拟结果。
