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为制备补充配方而对酸奶粉压缩特性的研究。

Study of compressibility properties of yogurt powder in order to prepare a complementary formulation.

作者信息

Moghbel Abdolhossein, Abbaspour Hamideh

机构信息

Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

Iran J Pharm Res. 2013 Summer;12(3):231-7.

Abstract

The aim of the present study was to prepare an oral tablet from liquid yogurt by reforming the physical properties for easy transportation, long-term storage and also as a complementary dairy product in case of nutrient deficiency. The liquid fresh yogurt was lyophilized at -40°C and 0.03 mTor pressure. The dry powder was homogenized by a 12 mesh size sieve. Some tests such as Carr's compressibility index, Hausner ratio and the angle of repose were applied to evaluate the flowability of yogurt powder. Study of the deformation of particles during forcing was done by calculation of the elastic recovery index. Carr's compressibility index percent and Hausner ratio were calculated 15 and 0.94, respectively. The range of repose angle was measured between19-20°. The elastic recovery was obtained up to 60%. Since the hardness of tablets increased by decreasing compression velocity, therefore yogurt powder might have a plastic deformation. The reduction of powder volume due to compression force was about 20% (p < 0.05). Tablets with low fat yogurt showed very good compressibility with 6-12 Strong-Cab (SC) hardness units. Producing a complementary formulated as a tablet from yogurt powder is possible and also maybe therapeutically effective against lactose-intolerance syndrome and preventing antibiotic-associated diarrhea.We suggest that for more authentic confirmation of the type of deformation, it should go through Heckel's equation analysis, too.

摘要

本研究的目的是通过改变液态酸奶的物理性质来制备口服片剂,以便于运输、长期储存,并且在营养缺乏时作为补充乳制品。液态新鲜酸奶在-40°C和0.03毫托压力下进行冻干。干粉通过12目筛进行均质化处理。应用了一些测试,如卡尔压缩指数、豪斯纳比和休止角,以评估酸奶粉的流动性。通过计算弹性恢复指数来研究颗粒在压制过程中的变形情况。卡尔压缩指数百分比和豪斯纳比分别计算为15和0.94。休止角范围在19 - 20°之间测量。弹性恢复率高达60%。由于片剂硬度随着压缩速度的降低而增加,因此酸奶粉可能发生了塑性变形。由于压缩力导致的粉末体积减少约为20%(p < 0.05)。低脂酸奶片剂表现出非常好的可压缩性,硬度为6 - 12强卡布(SC)硬度单位。由酸奶粉制备成补充片剂形式是可行的,并且可能对乳糖不耐受综合征具有治疗效果,并预防抗生素相关性腹泻。我们建议,为了更可靠地确认变形类型,还应通过赫克尔方程分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aa7/3813281/47c705d3ac98/ijpr-12-231-g001.jpg

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