Ghasemi Majid, Fatehi Farzad, Asadi Bahador, Khorvash Fariborz
Department of Neurology, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran J Neurol. 2012;11(1):25-7.
Amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease, is a progressive and devastating disease involving both lower and upper motor neurons, typically following a relentless progression towards death. Therefore, all efforts must be made by the clinician to exclude alternative and more treatable entities. ALS with laboratory abnormalities of uncertain significance is a subgroup of ALS that occurs in association with laboratory defined abnormalities that are of uncertain significance to the pathogenesis of ALS. The clinical utility of these abnormalities and what they ultimately mean in patients with ALS is discussed here, along with a review of the literature.
肌萎缩侧索硬化症（ALS）是运动神经元疾病最常见的形式，是一种累及上下运动神经元的进行性毁灭性疾病，通常会无情地走向死亡。因此，临床医生必须尽一切努力排除其他更可治疗的疾病。伴有意义不确定的实验室异常的ALS是ALS的一个亚组，它与实验室定义的对ALS发病机制意义不确定的异常有关。本文讨论了这些异常的临床实用性以及它们在ALS患者中的最终意义，并对相关文献进行了综述。
