Department of Neurology and Research Center of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Department of Neurology and Research Center of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
Life Sci. 2018 Jun 15;203:242-245. doi: 10.1016/j.lfs.2018.04.052. Epub 2018 Apr 27.
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disorder, characterized by the selective degeneration of upper and lower motor neurons. The common clinical symptoms of ALS are caused by the degeneration and dysfunction of motor neurons. With the progression of our understanding of the pathogenesis of the disease, an increasing number of extramotor phenotypes have been linked to ALS. It has long been believed that sensory neurons localized in the dorsal root ganglia are not involved in ALS. In addition, sensory nerve injury can clearly be considered as an important basis that does not support the diagnosis of ALS. However, accumulating evidence has revealed abnormalities in sensory neurons in both ALS patients and mouse models. This review summarizes the discoveries related to sensory nerve disturbance in ALS, which may provide insightful information that will help us better diagnose and understand the disease.
肌萎缩侧索硬化症（ALS）是最常见的运动神经元疾病，其特征是上下运动神经元的选择性退化。ALS 的常见临床症状是由运动神经元的退化和功能障碍引起的。随着我们对疾病发病机制的认识的不断深入，越来越多的运动外表型与 ALS 相关联。长期以来，人们认为定位于背根神经节的感觉神经元不参与 ALS。此外，感觉神经损伤可以明确地被认为是不支持 ALS 诊断的重要依据。然而，越来越多的证据表明，ALS 患者和小鼠模型中均存在感觉神经元异常。本综述总结了与 ALS 中感觉神经紊乱相关的发现，这些发现可能为我们提供有价值的信息，有助于我们更好地诊断和理解该疾病。
