du Preez J H, Greeff A S
J S Afr Vet Assoc. 1985 Dec;56(4):191-4.
The specific therapy of bacterial colonization of the teat canals of dried-off dairy cows by means of small amounts (33 mg/0.25 ml and 14 mg/0.1 ml) of a procain benzyl penicillin-dihydrostreptomycin sulphate combination has been investigated. Of 36 teat canals treated with 0.25 ml antibiotic preparation each, 24 (66.6%) were infected at the beginning of the dry period, whereas at its termination only 7 (19.4%) showed bacteriologically positive swab cultures. By treating a further 43 quarters with 0.1 ml quantities of an antibiotic preparation each, the prevalence of infection dropped from 32.5% to 14%. Untreated controls (20 quarters) showed no significant change. Cultures of teat canal swabs were generally twice as sensitive for indicating the presence of bacteria compared to foremilk sample cultures. Staphylococcus aureus was the most commonly isolated organism, followed by Streptococcus agalactiae, Corynebacterium bovis and Staphylococcus epidermidis.
研究了采用小剂量（33毫克/0.25毫升和14毫克/0.1毫升）的普鲁卡因苄青霉素-硫酸双氢链霉素组合对干奶期奶牛乳头管细菌定植进行特异性治疗的情况。在36个乳头管中，每个乳头管用0.25毫升抗生素制剂进行处理，其中24个（66.6%）在干奶期开始时受到感染，而在干奶期末尾，只有7个（19.4%）的拭子培养物在细菌学检查中呈阳性。通过对另外43个乳区，每个乳区用0.1毫升抗生素制剂进行处理，感染率从32.5%降至14%。未经处理的对照组（20个乳区）未显示出显著变化。与乳前样培养相比，乳头管拭子培养一般对指示细菌存在的敏感性要高两倍。金黄色葡萄球菌是最常分离出的微生物，其次是无乳链球菌、牛棒状杆菌和表皮葡萄球菌。
