在现实环境中，低剂量利拉鲁肽用于印度2型糖尿病患者的情况。
Low dose liraglutide in Indian patients with type 2 diabetes in the real world setting.
作者信息
Sanyal Debmalya, Majumdar Anirban
机构信息
Department of Endocrinology, KPC Medical College, Kolkata, West Bengal, India ; Department of Endocrinology, RTIICS, Kolkata, West Bengal, India.
出版信息
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S301-3. doi: 10.4103/2230-8210.119629.
Abstract
Liraglutide, a human glucagon-like peptide-1 receptor agonist, decreases glycosylated hemoglobin and causes weight loss. However, the cost of therapy and gastrointestinal side- effects such as nausea and diarrhea are important impediments to adherence and long-term compliance. We assessed the efficacy, safety and tolerability of low dose (0.6 mg) liraglutide in obese uncontrolled longstanding type 2 diabetes in Indian patients. Low dose liraglutide improved glycemic control and decreased weight. However, there was a significant drop out because of gastrointestinal intolerance and financial constraints.
摘要
利拉鲁肽是一种人胰高血糖素样肽-1受体激动剂，可降低糖化血红蛋白并导致体重减轻。然而，治疗成本以及诸如恶心和腹泻等胃肠道副作用是妨碍坚持治疗和长期依从性的重要因素。我们评估了低剂量（0.6毫克）利拉鲁肽对印度肥胖的、未得到控制的长期2型糖尿病患者的疗效、安全性和耐受性。低剂量利拉鲁肽改善了血糖控制并减轻了体重。然而，由于胃肠道不耐受和经济限制，出现了显著的退出情况。
相似文献
1
Low dose liraglutide in Indian patients with type 2 diabetes in the real world setting.在现实环境中，低剂量利拉鲁肽用于印度2型糖尿病患者的情况。
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S301-3. doi: 10.4103/2230-8210.119629.
2
Liraglutide therapy beyond glycemic control: an observational study in Indian patients with type 2 diabetes in real world setting.利拉鲁肽治疗超越血糖控制：真实世界环境中 2 型糖尿病印度患者的观察性研究。
Int J Gen Med. 2012;5:317-22. doi: 10.2147/IJGM.S27886. Epub 2012 Apr 13.
3
Long-term efficacy of liraglutide in Indian patients with Type 2 diabetes in a real-world setting.利拉鲁肽在印度2型糖尿病患者真实环境中的长期疗效。
Indian J Endocrinol Metab. 2016 Sep-Oct;20(5):595-599. doi: 10.4103/2230-8210.183825.
4
Efficacy and safety of liraglutide therapy in 195 Indian patients with type 2 diabetes in real world setting.利拉鲁肽治疗195例印度2型糖尿病患者在现实环境中的疗效与安全性。
Diabetes Metab Syndr. 2015 Jan-Mar;9(1):30-3. doi: 10.1016/j.dsx.2014.04.034. Epub 2014 May 22.
5
Clinical experience with Liraglutide in 196 patients with type 2 diabetes from a tertiary care center in India.来自印度一家三级医疗中心的196例2型糖尿病患者使用利拉鲁肽的临床经验。
Indian J Endocrinol Metab. 2014 Jan;18(1):77-82. doi: 10.4103/2230-8210.126572.
6
Liraglutide for treating type 1 diabetes.利拉鲁肽用于治疗1型糖尿病。
Expert Opin Biol Ther. 2016;16(4):579-90. doi: 10.1517/14712598.2016.1160050.
7
Effect of Adding Liraglutide vs Placebo to a High-Dose lnsulin Regimen in Patients With Type 2 Diabetes: A Randomized Clinical Trial.利拉鲁肽与安慰剂联合高剂量胰岛素治疗方案对 2 型糖尿病患者的影响：一项随机临床试验。
JAMA Intern Med. 2016 Jul 1;176(7):939-47. doi: 10.1001/jamainternmed.2016.1540.
8
Efficacy and tolerability of GLP-1 agonists in patients with type 2 diabetes mellitus: an Indian perspective.GLP-1激动剂在2型糖尿病患者中的疗效与耐受性：印度视角
Ther Adv Endocrinol Metab. 2014 Dec;5(6):159-65. doi: 10.1177/2042018814552657.
9
Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial.利拉鲁肽治疗血糖控制不佳的超重 1 型糖尿病成年患者的疗效和安全性（Lira-1）：一项随机、双盲、安慰剂对照试验。
Lancet Diabetes Endocrinol. 2016 Mar;4(3):221-232. doi: 10.1016/S2213-8587(15)00436-2. Epub 2015 Dec 3.
10
Glycemic Control and Weight Outcomes for Exenatide Once Weekly Versus Liraglutide in Patients with Type 2 Diabetes: A 1-Year Retrospective Cohort Analysis.度拉糖肽每周一次与利拉鲁肽治疗2型糖尿病患者的血糖控制及体重结局：一项1年回顾性队列分析
Clin Ther. 2016 Dec;38(12):2642-2651. doi: 10.1016/j.clinthera.2016.11.003. Epub 2016 Nov 23.
引用本文的文献
1
Liraglutide modulates cyclooxygenase and α7 acetylcholine receptors: in vitro and in silico insights into its anti-inflammatory role in LPS-induced inflammation in RAW 264.7 macrophages.利拉鲁肽调节环氧化酶和α7乙酰胆碱受体：对其在RAW 264.7巨噬细胞脂多糖诱导的炎症中抗炎作用的体外和计算机模拟研究
Naunyn Schmiedebergs Arch Pharmacol. 2025 May 31. doi: 10.1007/s00210-025-04225-5.
2
Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice.真实世界实践中抗肥胖药物疗效的比较。
Drug Des Devel Ther. 2024 Mar 18;18:845-858. doi: 10.2147/DDDT.S445415. eCollection 2024.
3
Early Insight Into the Retrospective Data of a Case Series on Type 2 Diabetes Mellitus on Alternate-Day Dosing of Oral Semaglutide: Utopia or Reality?关于口服司美格鲁肽隔日给药的2型糖尿病病例系列回顾性数据的早期洞察：乌托邦还是现实？
Cureus. 2023 Apr 3;15(4):e37065. doi: 10.7759/cureus.37065. eCollection 2023 Apr.
4
Liraglutide - Indian Experience.利拉鲁肽——印度经验
Indian J Endocrinol Metab. 2018 Nov-Dec;22(6):818-826. doi: 10.4103/ijem.IJEM_187_18.
5
Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes.胰高血糖素样肽-1受体激动剂停药原因：来自医生及其2型糖尿病患者的真实世界横断面调查数据
Diabetes Metab Syndr Obes. 2017 Sep 29;10:403-412. doi: 10.2147/DMSO.S141235. eCollection 2017.
本文引用的文献
1
Liraglutide Effect and Action in Diabetes (LEAD™) trial.利拉鲁肽在糖尿病中的疗效与作用（LEAD™）试验
Expert Rev Endocrinol Metab. 2009 Mar;4(2):119-129. doi: 10.1586/17446651.4.2.119.
2
Liraglutide therapy beyond glycemic control: an observational study in Indian patients with type 2 diabetes in real world setting.利拉鲁肽治疗超越血糖控制：真实世界环境中 2 型糖尿病印度患者的观察性研究。
Int J Gen Med. 2012;5:317-22. doi: 10.2147/IJGM.S27886. Epub 2012 Apr 13.
3
Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes.在日本 2 型糖尿病患者中，磺酰脲类药物的基础上加用每日 1 次的人胰高血糖素样肽-1 类似物利拉鲁肽，可改善血糖控制且不引起低血糖和体重变化。
Diabetes Obes Metab. 2010 Apr;12(4):341-7. doi: 10.1111/j.1463-1326.2009.01194.x.
4
Insights from the Liraglutide Clinical Development Program--the Liraglutide Effect and Action in Diabetes (LEAD) studies.利拉鲁肽临床开发项目的见解——利拉鲁肽在糖尿病中的作用及效果（LEAD）研究
Postgrad Med. 2009 May;121(3):16-25. doi: 10.3810/pgm.2009.05.1998.
5
Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study.利拉鲁肽、格列美脲与安慰剂联合二甲双胍治疗 2 型糖尿病的疗效和安全性比较：LEAD（利拉鲁肽在糖尿病中的作用和疗效）-2 研究。
Diabetes Care. 2009 Jan;32(1):84-90. doi: 10.2337/dc08-1355. Epub 2008 Oct 17.
Zotero 插件