Steinke B, Mau J
Klin Wochenschr. 1986 May 15;64(10):445-51. doi: 10.1007/BF01713170.
Using a regression model, the prognostic significance of clinical and biochemical parameters as well as of histology was analyzed in a group of 336 patients with Non-Hodgkin's lymphoma. A stochastic process model was used for evaluation of the course of disease. With respect to overall survival, serum-LDH-activity, performance status, and the histologically defined grade of malignancy were found to be the most important prognostic parameters, as well as age, though that to a lesser extent. In the course of disease, stage was the most relevant factor for achievement of a complete remission. In patients without remission, survival was determined mainly by histology and serum-LDH-activity; the latter was also of importance for duration of remission. Our study shows that histology is not the only prognostic factor in NHL but that other parameters, mainly serum-LDH-activity and performance status, also have to be considered in comparing different groups of patients.
利用回归模型，对336例非霍奇金淋巴瘤患者的临床、生化参数以及组织学的预后意义进行了分析。采用随机过程模型评估疾病进程。就总生存期而言，血清乳酸脱氢酶活性、体能状态、组织学确定的恶性程度等级以及年龄均被发现是最重要的预后参数，尽管年龄的重要性相对较小。在疾病进程中，分期是实现完全缓解的最相关因素。在未缓解的患者中，生存期主要由组织学和血清乳酸脱氢酶活性决定；后者对缓解期的持续时间也很重要。我们的研究表明，组织学并非非霍奇金淋巴瘤唯一的预后因素，在比较不同患者群体时，还必须考虑其他参数，主要是血清乳酸脱氢酶活性和体能状态。
