Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Allergy. 2014 Feb;69(2):265-8. doi: 10.1111/all.12317. Epub 2013 Nov 20.
A relationship between serum basal tryptase (sBT) levels, anaphylactic reactions, and clonal mast cell diseases was shown recently in adults with venom allergy, but the relationship between sBT levels and IgE-mediated food allergy and anaphylaxis is not known. In this study, children with food allergy (FA; n = 167) were analyzed in two groups according to the presence (FA+/A+; n = 79) or absence of anaphylaxis (FA+/A-; n = 88) and were compared with a control group (n = 113). Median sBT values in FA+/A+, FA+/A-, and control groups were 4.0 ng/ml (2.8-5.8), 3.6 (2.3-4.5), and 3.3 (2.4-4.4), respectively (P = 0.022). sBT measurements higher than the cutoff values of 5.7 and 14.5 were associated with 50% and 90% predicted probabilities, respectively, of moderate to severe anaphylaxis. Children with tree nuts/peanut allergies had significantly higher levels of sBT than children with milk and egg allergy (P = 0.022). Results suggest that sBT levels may predict moderate to severe anaphylaxis in children with food allergy, which may follow a particular pattern according to the food allergy phenotype.
最近的研究表明，血清基础类胰蛋白酶（sBT）水平与成人毒液过敏中的过敏反应和克隆性肥大细胞疾病之间存在关联，但 sBT 水平与 IgE 介导的食物过敏和过敏反应之间的关系尚不清楚。本研究根据食物过敏（FA）患儿是否伴有过敏反应（FA+/A+；n=79）或无过敏反应（FA+/A-；n=88）将其分为两组进行分析，并与对照组（n=113）进行比较。FA+/A+、FA+/A-和对照组的中位 sBT 值分别为 4.0ng/ml（2.8-5.8）、3.6（2.3-4.5）和 3.3（2.4-4.4）（P=0.022）。sBT 测量值高于 5.7 和 14.5 的截断值与中度至重度过敏反应的 50%和 90%预测概率相关。与牛奶和鸡蛋过敏的患儿相比，有树坚果/花生过敏的患儿 sBT 水平显著更高（P=0.022）。结果表明，sBT 水平可能预测食物过敏儿童的中重度过敏反应，其可能根据食物过敏表型呈现出特定的模式。
