Muraki Shigeyuki, Yoshimura Noriko, Akune Toru, Tanaka Sakae, Takahashi Ikuno, Fujiwara Saeko
Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, University of Tokyo , Tokyo , Japan.
Mod Rheumatol. 2014 Jul;24(4):657-61. doi: 10.3109/14397595.2013.843761. Epub 2013 Nov 5.
To identify the prevalence, incidence and progression of radiographic lumbar spondylosis (LS).
From the Adult Health Study conducted by the Radiation Effects Research Foundation, 1,204 participants aged 44-85 years who had lumbar spine radiographs in 1990-1992 were reexamined in 1998-2000 (mean 7.9-year interval). The radiographic severity of LS was determined by Kellgren/Lawrence (KL) grading.
In the overall population, the prevalence of radiographic KL ≥ 2 and ≥ 3 LS was 52.9% and 23.6%, respectively. KL ≥ 2 LS was more prevalent in men, whereas KL ≥ 3 LS was more prevalent in women. During the 8-year follow-up, the incidence of KL ≥ 2 LS in men and women was 65.5% and 46.6%, that of KL ≥ 3 LS was 27.3% and 29.5%, that of progressive LS was 31.3% and 34.0%, and multilevel LS was 44.9% and 33.4%, respectively. Body-mass index was a risk factor for both KL ≥ 2 and KL ≥ 3 LS, after adjusting for age and sex.
The present longitudinal study revealed the prevalence, incidence and progression of radiographic LS. Prevalence and incidence of KL ≥ 2 LS was higher in men than women, while, those of KL ≥ 3 were similar between men and women.
确定腰椎椎体关节强硬（LS）影像学表现的患病率、发病率及病情进展情况。
从辐射效应研究基金会开展的成人健康研究中选取1990 - 1992年接受过腰椎X光检查的1204名44 - 85岁参与者，于1998 - 2000年进行复查（平均间隔7.9年）。通过凯尔格伦/劳伦斯（KL）分级确定LS的影像学严重程度。
在总体人群中，KL分级≥2级和≥3级的LS患病率分别为52.9%和23.6%。KL≥2级的LS在男性中更为普遍，而KL≥3级的LS在女性中更为普遍。在8年的随访期间，男性和女性中KL≥2级LS的发病率分别为65.5%和46.6%，KL≥3级LS的发病率分别为27.3%和29.5%，病情进展型LS的发病率分别为31.3%和34.0%，多节段LS的发病率分别为44.9%和33.4%。在对年龄和性别进行校正后，体重指数是KL≥2级和KL≥3级LS的一个风险因素。
本纵向研究揭示了腰椎椎体关节强硬影像学表现的患病率、发病率及病情进展情况。KL≥2级LS的患病率和发病率男性高于女性，而KL≥3级的患病率和发病率在男性和女性中相似。
