Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.
Osteoarthritis Cartilage. 2012 Jul;20(7):712-8. doi: 10.1016/j.joca.2012.03.009. Epub 2012 Apr 4.
To determine the incidence of radiographic lumbar spondylosis (LS)and lower back pain, and their risk factors in Japan using a large-scale population from the nationwide cohort Research on Osteoarthritis/osteoporosis Against Disability (ROAD) Study.
Participants in the ROAD study who had been recruited between 2005 and 2007 were followed up with lumbar spine radiography for 3 years. A total of 2,282 paired radiographs (75% of the original sample) were scored using Kellgren and Lawrence (KL) grades, and the incidence and progression rate of radiographic LS was analyzed. The incidence of lower back pain was also examined. In addition, associations between risk factors and incident and progressive radiographic LS as well as incident lower back pain were tested.
Given a 3.3-year follow-up, the incidence of KL≥2 radiographic LS was 50.0% and 34.4% (15.3% and 10.5% per year), while that of KL≥3 LS was 15.3% and 23.7% (4.6% and 7.2% per year) in men and women, respectively. The progression rate of LS was 20.5% and 27.4% (6.2% and 8.3% per year) in men and in women, respectively. In addition, the incidence of lower back pain was 28.3% and 31.2% (8.6% and 9.5% per year) in men and women. Lower back pain was not significantly associated with incident radiographic LS, while a more severe KL grade at baseline was associated with incident lower back pain.
The present longitudinal study revealed a high incidence of radiographic LS in Japan.
使用来自全国性队列研究——骨关节炎/骨质疏松症与残疾研究（ROAD）的大规模人群，确定日本放射学腰椎（LS）和下腰痛的发生率及其危险因素。
ROAD 研究于 2005 年至 2007 年间招募参与者，并在 3 年内对其腰椎进行放射摄影随访。共对 2282 对放射照片（原始样本的 75%）进行了 Kellgren 和 Lawrence（KL）分级评分，分析了放射学 LS 的发生率和进展率。还检查了下腰痛的发生率。此外，还测试了危险因素与放射学 LS 的新发和进展以及下腰痛的发生之间的关联。
经过 3.3 年的随访，KL≥2 级放射学 LS 的发生率为 50.0%和 34.4%（每年 15.3%和 10.5%），而 KL≥3 LS 的发生率分别为男性和女性的 15.3%和 23.7%（每年 4.6%和 7.2%）。LS 的进展率分别为男性和女性的 20.5%和 27.4%（每年 6.2%和 8.3%）。此外，男性和女性的下腰痛发生率分别为 28.3%和 31.2%（每年 8.6%和 9.5%）。下腰痛与新发放射学 LS 无显著相关性，而基线时更严重的 KL 分级与新发下腰痛相关。
本纵向研究揭示了日本放射学 LS 的高发生率。
