Miyata Katsumi, Koga Takayuki, Aso Sunao, Hoshuyama Satsuki, Ajimi Syozo, Furukawa Kotaro
CERI Hita, Chemicals Evaluation and Research Institute , Hita , Japan.
Drug Chem Toxicol. 2014 Jul;37(3):303-10. doi: 10.3109/01480545.2013.851690. Epub 2013 Nov 19.
A subchronic (180-day) toxicity study was conducted to evaluate the effects of ethyl tertiary-butyl ether (ETBE), a biomass fuel, in male and female rats. ETBE was administered at dose levels of 0, 5, 25, 100 and 400 mg/kg/body weight (b.w.)/day by gavage. No treatment-related adverse effects were observed at 5, 25 or 100 mg/kg. Centrilobular hypertrophy of hepatocytes was observed in males and females and their relative liver weights were increased, suggesting enhanced metabolic activity. From these results, we concluded that the no observed adverse effect level of ETBE was 100 mg/kg b.w./day under the conditions tested.
进行了一项亚慢性（180天）毒性研究，以评估生物质燃料乙基叔丁基醚（ETBE）对雄性和雌性大鼠的影响。通过灌胃给予ETBE的剂量水平为0、5、25、100和400毫克/千克体重/天。在5、25或100毫克/千克剂量下未观察到与治疗相关的不良反应。在雄性和雌性大鼠中均观察到肝细胞中央小叶肥大，且它们的相对肝脏重量增加，表明代谢活性增强。根据这些结果，我们得出结论，在所测试的条件下，ETBE的未观察到不良反应水平为100毫克/千克体重/天。
