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Health assessment of gasoline and fuel oxygenate vapors: immunotoxicity evaluation.汽油和燃料含氧化合物蒸气的健康评估：免疫毒性评估。
Regul Toxicol Pharmacol. 2014 Nov;70(2 Suppl):S43-7. doi: 10.1016/j.yrtph.2014.04.010. Epub 2014 May 2.
2
A subchronic (180-day) oral toxicity study of ethyl tertiary-butyl ether, a bioethanol, in rats.一项关于生物乙醇叔丁基乙醚对大鼠的亚慢性（180天）经口毒性研究。
Drug Chem Toxicol. 2014 Jul;37(3):303-10. doi: 10.3109/01480545.2013.851690. Epub 2013 Nov 19.
3
Prenatal developmental toxicity study of ethyl tertiary-butyl ether in rats.大鼠乙基叔丁基醚的产前发育毒性研究。
Drug Chem Toxicol. 2014 Jan;37(1):17-24. doi: 10.3109/01480545.2013.806527. Epub 2013 Jul 10.
4
Calcium lignosulphonate: re-evaluation of relevant endpoints to re-confirm validity and NOAEL of a 90-day feeding study in rats.钙木素磺酸盐：重新评估相关终点以重新确认大鼠 90 天喂养研究的有效性和无可见不良作用水平。
Regul Toxicol Pharmacol. 2013 Aug;66(3):286-99. doi: 10.1016/j.yrtph.2013.04.007. Epub 2013 May 7.
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Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of methyl acetate.《化妆品成分评估专家小组关于醋酸甲酯安全性评估的最终报告》
Int J Toxicol. 2012 Jul-Aug;31(4 Suppl):112S-36S. doi: 10.1177/1091581812444142.
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Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice.亚慢性吸入乙基叔丁基醚对小鼠脾细胞的影响。
Int J Immunopathol Pharmacol. 2011 Oct-Dec;24(4):837-47. doi: 10.1177/039463201102400403.
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Oral subchronic immunotoxicity study of ethyl tertiary butyl ether in the rat.大鼠中乙基叔丁基醚的口服亚慢性免疫毒性研究。
J Immunotoxicol. 2011 Oct-Dec;8(4):298-304. doi: 10.3109/1547691X.2011.598480. Epub 2011 Aug 10.
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Ethyl t-butyl ether: review of reproductive and developmental toxicity.乙基叔丁基醚：生殖与发育毒性综述
Birth Defects Res B Dev Reprod Toxicol. 2010 Jun;89(3):239-63. doi: 10.1002/bdrb.20246.
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A one-generation reproductive toxicity study of ethyl tertiary butyl ether in rats.大鼠乙基叔丁基醚的一代生殖毒性研究。
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关于评估物质作为食用油脂可接受的先前货物的科学意见。

Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils.

作者信息

Knutsen Helle Katrine, Alexander Jan, Barregård Lars, Bignami Margherita, Brüschweiler Beat, Ceccatelli Sandra, Cottrill Bruce, Dinovi Michael, Edler Lutz, Hogstrand Christer, Hoogenboom Laurentius Ron, Nebbia Carlo, Oswald Isabelle, Petersen Annette, Rose Martin, Roudot Alain-Claude, Schwerdtle Tanja, Vollmer Günter, Wallace Heather, Grasl-Kraupp Bettina, Grob Konrad, Penninks André, Binaglia Marco, Roldán Torres Ruth, Vleminckx Christiane

出版信息

EFSA J. 2017 Jan 18;15(1):e04656. doi: 10.2903/j.efsa.2017.4656. eCollection 2017 Jan.

DOI:10.2903/j.efsa.2017.4656
PMID:32625253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7009818/
Abstract

Shipping of edible fats and oils into Europe is permitted in bulk tanks, provided that the previous cargo is included in a positive list. The European Commission requested EFSA to evaluate the acceptability as previous cargoes for fats and oils the substances calcium lignosulphonate, methyl acetate, ethyl -butyl ether (ETBE) and ammonium sulphate. The evaluation was based on the same criteria as those used for the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils. Methyl acetate and ETBE meet the criteria for acceptability as previous cargoes. Due to uncertainties, mainly with regard to the composition and toxicity of the low molecular mass fraction, and the fact that the toxicological database is limited to the 40-65 grade and does not cover all grades of calcium lignosulphonate shipped as previous cargoes, the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) concluded that calcium lignosulphonate does not meet the criteria for acceptability as a previous cargo. Only food-grade ammonium sulphate meets the criteria for acceptability as a previous cargo due to uncertainties about impurities in other (non-food) grades.

摘要

食用油脂以散装罐形式运往欧洲是允许的，前提是前一批货物包含在一份正面清单中。欧盟委员会要求欧洲食品安全局评估木质素磺酸钙、乙酸甲酯、乙基叔丁基醚（ETBE）和硫酸铵作为油脂前一批货物的可接受性。该评估基于与用于评估欧盟委员会指令96/3/EC附件中目前列入清单的物质作为食用油脂可接受前一批货物所使用的相同标准。乙酸甲酯和ETBE符合作为前一批货物的可接受标准。由于存在不确定性，主要涉及低分子质量部分的组成和毒性，以及毒理学数据库仅限于40 - 65级且未涵盖作为前一批货物运输的所有等级的木质素磺酸钙这一事实，欧洲食品安全局食物链污染物小组（CONTAM小组）得出结论，木质素磺酸钙不符合作为前一批货物的可接受标准。由于其他（非食品）等级中杂质存在不确定性，只有食品级硫酸铵符合作为前一批货物的可接受标准。