Matsui Kiyohiro, Tachibana Hisao, Yamanishi Toshiyuki, Oguru Miyako, Toda Kazuo, Okuda Bungo, Oka Nobuyuki
Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Clin Neurol Neurosurg. 2013 Dec;115(12):2524-7. doi: 10.1016/j.clineuro.2013.10.013. Epub 2013 Oct 31.
To investigate the prevalence and clinical correlates of anhedonia in patients with Parkinson's disease (PD) and to also examine the relationship between anhedonia and the QOL.
One hundred and seventeen patients with PD completed the Snaith-Hamilton Pleasure Scale (SHAPS), the State-Trait Anxiety Inventory (STAI), the Beck Depression Inventory Second Edition (BDI-II), Starkstein's Apathy Scale (AS) and a quality of life (QOL) battery. Hoehn and Yahr (HY) staging, the Unified Parkinson's Disease Rating Scale (UPDRS) and the Mini-Mental State Examination (MMSE) were administered on the same day.
Anhedonia (SHAPS score≥3) was diagnosed in 15% of the patients. The SHAPS score was found to be significantly correlated with the HY stage and the UPDRS (I, IVB, IVC, total), BDI-II, AS and STAI (State, Trait) scores. A multivariate analysis revealed that the BDI-II and STAI (Trait) scores significantly influenced the SHAPS scores. The SHAPS scores were found to be negatively correlated with the QOL.
These findings indicate that anhedonia is associated with depression and anxiety. In addition, recognizing anhedonia in patients with PD is important since it may have a negative effect on the QOL.
探讨帕金森病（PD）患者快感缺乏的患病率及其临床相关因素，并研究快感缺乏与生活质量（QOL）之间的关系。
117例PD患者完成了斯奈斯 - 汉密尔顿快感量表（SHAPS）、状态 - 特质焦虑量表（STAI）、贝克抑郁量表第二版（BDI-II）、斯塔克斯坦淡漠量表（AS）以及一组生活质量（QOL）测评。同一天进行了霍恩和雅尔（HY）分期、统一帕金森病评定量表（UPDRS）以及简易精神状态检查表（MMSE）评估。
15%的患者被诊断为快感缺乏（SHAPS评分≥3）。发现SHAPS评分与HY分期、UPDRS（I、IVB、IVC、总分）、BDI-II、AS以及STAI（状态、特质）评分显著相关。多因素分析显示，BDI-II和STAI（特质）评分对SHAPS评分有显著影响。发现SHAPS评分与QOL呈负相关。
这些发现表明快感缺乏与抑郁和焦虑有关。此外，认识到PD患者的快感缺乏很重要，因为它可能对QOL产生负面影响。
