Nagayama Hiroshi, Maeda Tetsuya, Uchiyama Tsuyoshi, Hashimoto Masaya, Nomoto Nobuatsu, Kano Osamu, Takahashi Tatsuya, Terashi Hiroo, Hamada Shinsuke, Hasegawa Takafumi, Hatano Taku, Takahashi Tetsuya, Baba Yasuhiko, Sengoku Renpei, Watanabe Hirohisa, Inoue Manabu, Kadowaki Taro, Kaneko Satoshi, Shimura Hideki, Kubo Shin-Ichiro
Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Department of Neurology and Movement Disorder Research, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan.
J Neurol Sci. 2017 Jan 15;372:403-407. doi: 10.1016/j.jns.2016.10.051. Epub 2016 Nov 3.
Anhedonia is one of the non-motor symptoms observed in the Parkinson's disease (PD). However, there is no clear relationship between anhedonia and its correlation with other symptoms of PD. The aim of this study is to evaluate the characteristics of anhedonia and its correlation with clinical aspects of PD in a relatively large cohort. We enrolled 318 patients with PD and 62 control subjects for this study. Patients and subjects were tested using the Snaith-Hamilton Pleasure Scale Japanese version and the Beck Depression Inventory 2nd edition for the assessment of anhedonia and depression. We also investigated the correlation among clinical aspects of PD, anhedonia, and depression in patients with PD. The Snaith-Hamilton Pleasure Scale Japanese version and the Beck Depression Inventory 2nd edition scores were significantly higher in patients with PD than in control subjects (p=0.03 and p=0.0006, respectively). All PD patients with anhedonia had a significantly higher score on the unified Parkinson's disease rating scale (UPDRS) parts I and II compared to PD patients without anhedonia. Additionally, all PD patients with depression scored significantly higher on UPDRS part I-IV than PD patients without depression. The patients with anhedonia and without depression had mild motor severity and their treatment was relatively low dosage. These results suggest that anhedonia and depression are slightly linked, but not the same. PD patients with only anhedonia may be closely linked apathy found in untreated early stages of PD.
快感缺失是帕金森病（PD）中观察到的非运动症状之一。然而，快感缺失与其与PD其他症状的相关性之间没有明确的关系。本研究的目的是在一个相对较大的队列中评估快感缺失的特征及其与PD临床方面的相关性。我们招募了318例PD患者和62名对照受试者进行本研究。使用日本版的斯奈斯 - 汉密尔顿愉悦量表和贝克抑郁量表第二版对患者和受试者进行测试，以评估快感缺失和抑郁情况。我们还研究了PD患者的PD临床方面、快感缺失和抑郁之间的相关性。PD患者的日本版斯奈斯 - 汉密尔顿愉悦量表和贝克抑郁量表第二版得分显著高于对照受试者（分别为p = 0.03和p = 0.0006）。与无快感缺失的PD患者相比，所有有快感缺失的PD患者在统一帕金森病评定量表（UPDRS）第一部分和第二部分的得分显著更高。此外，所有有抑郁的PD患者在UPDRS第一至四部分的得分显著高于无抑郁的PD患者。有快感缺失但无抑郁的患者运动严重程度较轻，其治疗剂量相对较低。这些结果表明，快感缺失和抑郁略有联系，但并不相同。仅患有快感缺失的PD患者可能与PD未治疗早期发现的淡漠密切相关。
