Kitamura Shin, Nagayama Hiroshi
Department of Neurology, Nippon Medical School Musashikosugi Hospital.
Department of Neurology, Nippon Medical School.
Seishin Shinkeigaku Zasshi. 2013;115(11):1135-41.
Depression affects Parkinson's disease (PD) patient's QOL. Although it changes with the diagnostic criteria used, the frequency of depression in PD is approximately 10-30%. Anhedonia is characteristic in PD. According to research on anhedonia in PD using the Snaith-Hamilton Pleasure Scale (SHAPS), the positive ratio of anhedonia is high in PD. The SHAPS score significantly correlates with the severity of PD and duration of the disease. An examination of the literature on depression before the development of motor symptoms of PD revealed that the risk of PD is high in patients with a history of depression. Pathologically, the substantia nigra is affected in the later stages and raphe nuclei are affected in the early stages. This suggests that depression is a prodromal symptom of PD.
抑郁症会影响帕金森病（PD）患者的生活质量。尽管其发生率会因所使用的诊断标准而有所变化，但PD患者中抑郁症的发生率约为10%-30%。快感缺失是PD的特征性表现。根据使用斯奈斯-汉密尔顿愉悦量表（SHAPS）对PD患者快感缺失的研究，PD患者中快感缺失的阳性率较高。SHAPS评分与PD的严重程度及病程显著相关。对PD运动症状出现之前的抑郁症相关文献研究发现，有抑郁症病史的患者患PD的风险较高。在病理方面，黑质在后期受到影响，中缝核在早期受到影响。这表明抑郁症是PD的前驱症状。
