Cho Moonjae, Yoon Hyuk, Park Mijoo, Kim Young Hwa, Lim Yoongho
Department of Biochemistry, School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea.
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea.
Phytomedicine. 2014 Mar 15;21(4):560-9. doi: 10.1016/j.phymed.2013.10.006. Epub 2013 Nov 16.
Cell migration plays an important role in multicellular development and preservation. Because wound healing requires cell migration, compounds promoting cell migration can be used for wound repair therapy. Several plant-derived polyphenols are known to promote cell migration, which improves wound healing. Previous studies of flavonoids on cell lines have focused on their inhibitory effects and not on wound healing. In addition, studies of flavonoids on wound healing have been performed using mixtures. In this study, individual flavonoids were used for cellular migration measurements. Relationships between the cell migration effects of flavonoids and their structural properties have never been reported. Here, we investigated the migration of keratinocytes caused by 100 flavonoids and examined their relationships using hologram quantitative structure-activity relationships. The structural conditions responsible for efficient cell migration on keratinocyte cell lines determined from the current study will facilitate the design of flavonoids with improved activity.
细胞迁移在多细胞生物的发育和维持过程中发挥着重要作用。由于伤口愈合需要细胞迁移，因此促进细胞迁移的化合物可用于伤口修复治疗。已知几种植物来源的多酚能促进细胞迁移，从而加速伤口愈合。先前关于黄酮类化合物对细胞系的研究主要集中在其抑制作用，而非伤口愈合方面。此外，关于黄酮类化合物对伤口愈合的研究一直是使用混合物进行的。在本研究中，我们使用单一黄酮类化合物来测量细胞迁移。黄酮类化合物的细胞迁移效应与其结构特性之间的关系此前从未有过报道。在此，我们研究了100种黄酮类化合物引起的角质形成细胞迁移情况，并使用全息定量构效关系研究了它们之间的关系。根据本研究确定的对角质形成细胞系有效细胞迁移起作用的结构条件，将有助于设计出活性更高的黄酮类化合物。
