Psychiatry Department, SUNY Upstate Medical University, Syracuse, New York, USA.
CNS Spectr. 2013 Dec;18 Suppl 1:25-32; quiz 33. doi: 10.1017/S1092852913000734. Epub 2013 Nov 19.
The goal of this brief review is to explain the role of monoamine oxidase enzymes in the neurobiology, etiology, and presentation of psychiatric illnesses, primarily major depressive disorder. This article will initially focus on the basic science and function of the monoamine oxidase system and some proposed neuropsychiatric symptoms that may arise if this enzyme system is altered by genetic predisposition. These findings and theories will next be translationally discussed in regard to clinical application pertaining to enzyme inhibition and the treatment of major depressive and other psychiatric disorders.
本文的目的是阐述单胺氧化酶在神经生物学、病因学和精神疾病（主要是重度抑郁症）中的作用。本文首先将重点介绍单胺氧化酶系统的基础科学和功能，以及如果这种酶系统因遗传易感性而发生改变，可能会出现哪些神经精神症状。然后，将根据这些发现和理论，从酶抑制和重度抑郁症及其他精神疾病的治疗等临床应用方面进行探讨。
