Murphy D L, Garrick N A, Aulakh C S, Cohen R M
J Clin Psychiatry. 1984 Jul;45(7 Pt 2):37-43.
Recent studies have provided almost conclusive evidence for the existence of the two separate MAO isozymes previously postulated to exist on the basis of indirect evidence. Important differences in the proportions and distribution of these two enzyme forms across species and in various tissues are responsible for some puzzling anomalies in earlier studies and contribute to differences in behavioral responses, blood pressure changes, and toxic responses to tyramine and other sympathomimetic agents. Substrate-selective, irreversible inhibitors, as well as several new classes of reversible MAO-A and MAO-B selective inhibitors, may provide a spectrum of clinical effects different from the nonselective irreversible MAO inhibitors.
最近的研究几乎提供了确凿证据，证明先前基于间接证据推测存在的两种独立的单胺氧化酶（MAO）同工酶确实存在。这两种酶形式在不同物种和各种组织中的比例及分布存在重要差异，这是早期研究中一些令人困惑的异常现象的原因，也导致了行为反应、血压变化以及对酪胺和其他拟交感神经药的毒性反应存在差异。底物选择性、不可逆抑制剂以及几类新型的可逆性MAO - A和MAO - B选择性抑制剂，可能会产生与非选择性不可逆MAO抑制剂不同的一系列临床效果。
