Jain Deepti
Department of Gynaecology, Chotu Ram Hospital, Rohtak, Haryana, India.
BMJ Case Rep. 2013 Nov 19;2013:bcr2013201298. doi: 10.1136/bcr-2013-201298.
A 24-year-old woman with 21-hydroxylase deficient classic congenital adrenal hyperplasia, simple virilising form presented with secondary infertility. One year ago she had a spontaneous miscarriage in the second trimester of pregnancy. This time she conceived with prednisolone 5 mg and clomiphene citrate 100 mg. She was then continued with prednisolone during pregnancy. She had a spontaneous preterm delivery at 33 weeks. There was a marginal increase in the dose of prednisolone during pregnancy. There was no worsening of insulin resistance during pregnancy despite prednisolone administration. A normal healthy female infant was born and is being followed up on for ill-effects, if any, of maternal glucocorticoid administration during pregnancy. The baby girl has normal female external genitalia.
一名24岁患有21-羟化酶缺乏的经典型先天性肾上腺皮质增生症（单纯男性化型）的女性出现继发性不孕。一年前她在妊娠中期自然流产。此次她在服用5毫克泼尼松龙和100毫克枸橼酸氯米芬后怀孕。孕期她继续服用泼尼松龙。她在33周时自然早产。孕期泼尼松龙剂量有少量增加。尽管服用了泼尼松龙，但孕期胰岛素抵抗并未加重。一名健康的女婴出生，目前正在对其进行随访，观察孕期母亲使用糖皮质激素是否会产生任何不良影响。女婴的女性外生殖器正常。
