Huang Sha, Yi Feng-Ming, Zhou Rui, Chen Min, Lei Yuan, Zhao Jun-Zhang, Zhang Heng, Xia Bing
Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, Wuhan, China.
Saudi Med J. 2013 Nov;34(11):1161-6.
To evaluate the diagnostic utility of platelet count (PLT), mean platelet volume (MPV), and red cell distribution width (RDW) in patients with active Crohn's disease (CD) and intestinal tuberculosis (ITB).
This study was conducted in the Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. Sixty-eight patients with active CD, 35 with ITB, and 22 as control group were recruited. Blood routine test including white blood cell, red blood cell, PLT, MPV, RDW, and so forth was investigated.
Patients with active CD and ITB have increased PLT and RDW (both p<0.001), and decreased MPV (p=0.002). The RDW performed preferably in predicting both active CD (odds ratio [OR]=2.390, p=0.007), and ITB (OR=2.338, p=0.017), and had better diagnostic value (area under the receiver operating characteristics curve [AUC] - 0.812; p<0.001) than CRP (AUC - 0.716; p=0.007) and ESR (AUC - 0.804; p<0.001) in ITB diagnosis.
Among the laboratory markers, RDW not only possessed the favorable capability to predict active CD, but also showed outstanding predicting capability, and good diagnostic value in ITB.
评估血小板计数（PLT）、平均血小板体积（MPV）和红细胞分布宽度（RDW）在活动性克罗恩病（CD）和肠结核（ITB）患者中的诊断效用。
本研究在武汉大学中南医院消化内科进行。招募了68例活动性CD患者、35例ITB患者和22例作为对照组。进行了包括白细胞、红细胞、PLT、MPV、RDW等在内的血常规检查。
活动性CD和ITB患者的PLT和RDW升高（均p<0.001），MPV降低（p=0.002）。RDW在预测活动性CD（比值比[OR]=2.390，p=0.007）和ITB（OR=2.338，p=0.017）方面表现较好，并且在ITB诊断中比CRP（AUC - 0.716；p=0.007）和ESR（AUC - 0.804；p<0.001）具有更好的诊断价值（受试者工作特征曲线下面积[AUC] - 0.812；p<0.001）。
在实验室指标中，RDW不仅具有预测活动性CD的良好能力，而且在ITB中显示出出色的预测能力和良好的诊断价值。
