平均血小板体积作为轮状病毒胃肠炎患儿炎症的阴性标志物。

Mean platelet volume as a negative marker of inflammation in children with rotavirus gastroenteritis.

作者信息

Tanju Celik, Ekrem Güler, Berksoy Emel Atas, Nur Arslan

机构信息

Department of Pediatric Emergency, Dr. Behcet Uz Children's Hospital, Izmir.

Department of Pediatric Emergency, Dr. Sütçü Imam University, Faculty of Medicine, Maras.

出版信息

Iran J Pediatr. 2014 Oct;24(5):617-22. Epub 2014 Oct 28.

PMID:25793071

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4359417/

Abstract

OBJECTIVE

Mean platelet volume (MPV) is a determinant of inflammation. The aim of the present study was to investigate the MPV levels in children with rotavirus gastroenteritis and to evaluate the possible relationship between MPV and severity of gastroenteritis.

METHODS

Children diagnosed with acute rotavirus gastroenteritis and healthy controls were enrolled in this study. Patients were classified into three disease severity groups based on their Vesikari score (<7 mild, 7-10 moderate and >11 severe). Rotavirus was determined in fresh stool samples using ELISA test. Leukocyte and platelet counts, MPV and C-reactive protein (CRP) levels were assessed for all children.

FINDINGS

A total of 151 patients with rotavirus gastroenteritis (mean age 2.41± 0.14 years) and 80 healthy controls (mean age 2.63±0.22 years, P=0.129) were enrolled. MPV levels of children with rotavirus gastroenteritis were significantly lower than those of healthy peers (7.48±0.04 vs 7.79±0.07 fl, P=0.000). MPV levels were not significantly different among three gastroenteritis groups. Gastroenteritis score was positively correlated with leukocyte (r=0.670, P<0.01) and platelet count (r=0.159, P<0.05) and CRP level (r=0.256, P<0.01) in patients group. MPV was inversely correlated with platelet count. There was no significant correlation between MPV and gastroenteritis score.

CONCLUSION

MPV levels were significantly lower in children with rotavirus gastroenteritis compared to controls. MPV can be used as a negative acute phase reactant in children with rotavirus gastroenteritis.

摘要

目的

平均血小板体积（MPV）是炎症的一个决定因素。本研究的目的是调查轮状病毒胃肠炎患儿的MPV水平，并评估MPV与胃肠炎严重程度之间的可能关系。

方法

本研究纳入了诊断为急性轮状病毒胃肠炎的儿童和健康对照。根据Vesikari评分（<7为轻度，7 - 10为中度，>11为重度）将患者分为三个疾病严重程度组。使用ELISA试验在新鲜粪便样本中检测轮状病毒。对所有儿童评估白细胞和血小板计数、MPV和C反应蛋白（CRP）水平。

结果

共纳入151例轮状病毒胃肠炎患者（平均年龄2.41±0.14岁）和80例健康对照（平均年龄2.63±0.22岁，P = 0.129）。轮状病毒胃肠炎患儿的MPV水平显著低于健康同龄人（7.48±0.04对7.79±0.07 fl，P = 0.000）。三个胃肠炎组之间的MPV水平无显著差异。在患者组中，胃肠炎评分与白细胞（r = 0.670，P < 0.01）、血小板计数（r = 0.159，P < 0.05）和CRP水平（r = 0.256，P < 0.01）呈正相关。MPV与血小板计数呈负相关。MPV与胃肠炎评分之间无显著相关性。